Summary

This strain contains 20 protein-level mutations:

  • 6 mutations in Spike protein: L5F, HV 69-70 deletion, T95I, D614G, T859N, D950H
  • 2 mutations in N protein: T205I, M234I
  • 2 mutations in NS3 protein: P42L, Q57H
  • 2 mutations in NS8 protein: T11I, A51S
  • 1 mutation in NS9c protein: L52F
  • 1 mutation in NSP2 protein: T85I
  • 3 mutations in NSP4 protein: K399E, L438P, A446V
  • 2 mutations in NSP6 protein: SGF 106-108 deletion, V278I
  • 1 mutation in NSP12 protein: P323L

We identified all possible linear viral peptides affected by these mutations. Whenever it was possible, we matched the reference peptide with the mutated one. For example, D -> L mutation transformed SDNGPQNQR to SLNGPQNQR. Cases when it was not meaningful included deletions and insertions at the flanks of the peptide, e.g., HV deletion in NVTWFHAIHV peptide.

Then, we predicted binding affinities between the selected peptides and frequent HLA alleles. Predictions were made with NetMHCpan-4.1 and NetMHCIIpan-4.0. The binding affinities were classifies into three groups:

  1. Tight binding (IC50 affinity ≤ 50 nM)
  2. Moderate binding (50 nM < IC50 affinity ≤ 500 nM)
  3. Weak/no binding (IC50 affinity > 500 nM)

Here we report HLA-peptide interactions whose affinity was altered by at least two folds. Note that mutations with empty set of altered interactions are not showed.

The total number of interactions between HLA-DRB1*15:01 and peptides affected by the mutations

Weaker binding was found for 164 epitopes, while stronger binding was found for 191 entries. There are 916 tight binders for the HLA-DRB1*15:01 in the reference immunopeptidome (IC50 affinity ≤ 50 nM); 32 of them became non-tight binders (3.5%) and 0 novel tight binders appeared (0.0%). To avoid possible divisions by zero, we used + 1 regularization term in denominators when calculating percentages.

HLA-DRB1*15:01

Spike protein

HV 69-70 deletion

Reference  RSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFAST
           |||||||||||||||||||||||||  |||||||||||||||||||||||||
Mutated    RSSVLHSTQDLFLPFFSNVTWFHAI‑‑SGTNGTKRFDNPVLPFNDGVYFASI

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 PFFSNVTWFHAIHVS PFFSNVTWFHAIS 19 -
HLA-DRB1*15:01 FFSNVTWFHAIHVSG FFSNVTWFHAISG 19 -
HLA-DRB1*15:01 FSNVTWFHAIHVSGT FSNVTWFHAISGT 19 -
HLA-DRB1*15:01 SNVTWFHAIHVSGTN SNVTWFHAISGTN 26 -
HLA-DRB1*15:01 LPFFSNVTWFHAIHV LPFFSNVTWFHAI 30 -
HLA-DRB1*15:01 FFSNVTWFHAIHVSGT FFSNVTWFHAISGT 35 -
HLA-DRB1*15:01 PFFSNVTWFHAIHVSG PFFSNVTWFHAISG 36 -
HLA-DRB1*15:01 LPFFSNVTWFHAIHVS LPFFSNVTWFHAIS 37 -
HLA-DRB1*15:01 FSNVTWFHAIHVSGTN FSNVTWFHAISGTN 37 -
HLA-DRB1*15:01 NVTWFHAIHVSGTNG NVTWFHAISGTNG 37 -
HLA-DRB1*15:01 TQDLFLPFFSNVTWFHAIHV - 43 -
HLA-DRB1*15:01 LFLPFFSNVTWFHAIHV - 50 -
HLA-DRB1*15:01 SNVTWFHAIHVSGTNG SNVTWFHAISGTNG 57 -
HLA-DRB1*15:01 FLPFFSNVTWFHAIHV FLPFFSNVTWFHAI 60 -
HLA-DRB1*15:01 QDLFLPFFSNVTWFHAIHV - 64 -
HLA-DRB1*15:01 STQDLFLPFFSNVTWFHAIH - 72 -
HLA-DRB1*15:01 STQDLFLPFFSNVTWFHAIHVS STQDLFLPFFSNVTWFHAIS - 73
HLA-DRB1*15:01 TQDLFLPFFSNVTWFHAIHVSG TQDLFLPFFSNVTWFHAISG - 76
HLA-DRB1*15:01 QDLFLPFFSNVTWFHAIHVSGT QDLFLPFFSNVTWFHAISGT - 81
HLA-DRB1*15:01 NVTWFHAIHVSGTNGT NVTWFHAISGTNGT 81 -
HLA-DRB1*15:01 DLFLPFFSNVTWFHAIHVSGTN DLFLPFFSNVTWFHAISGTN - 101
HLA-DRB1*15:01 DLFLPFFSNVTWFHAIH - 104 -
HLA-DRB1*15:01 TQDLFLPFFSNVTWFHAIH - 111 -
HLA-DRB1*15:01 TQDLFLPFFSNVTWFHAIHVS TQDLFLPFFSNVTWFHAIS - 112
HLA-DRB1*15:01 LFLPFFSNVTWFHAIHVSGTNG LFLPFFSNVTWFHAISGTNG - 117
HLA-DRB1*15:01 VTWFHAIHVSGTNGT VTWFHAISGTNGT 123 -
HLA-DRB1*15:01 QDLFLPFFSNVTWFHAIHVSG QDLFLPFFSNVTWFHAISG - 124
HLA-DRB1*15:01 DLFLPFFSNVTWFHAIHV - 135 -
HLA-DRB1*15:01 FLPFFSNVTWFHAIHVSGTNGT FLPFFSNVTWFHAISGTNGT - 137
HLA-DRB1*15:01 LPFFSNVTWFHAIHVSGTNGTK LPFFSNVTWFHAISGTNGTK - 150
HLA-DRB1*15:01 FLPFFSNVTWFHAIH FLPFFSNVTWFHAI 155 -
HLA-DRB1*15:01 PFFSNVTWFHAIHVSGTNGTKR PFFSNVTWFHAISGTNGTKR - 156
HLA-DRB1*15:01 DLFLPFFSNVTWFHAIHVSGT DLFLPFFSNVTWFHAISGT - 178
HLA-DRB1*15:01 FFSNVTWFHAIHVSGTNGTKRF FFSNVTWFHAISGTNGTKRF - 182
HLA-DRB1*15:01 LFLPFFSNVTWFHAIH - 191 -
HLA-DRB1*15:01 LFLPFFSNVTWFHAIHVSGTN LFLPFFSNVTWFHAISGTN - 192
HLA-DRB1*15:01 FLPFFSNVTWFHAIHVSGTNG FLPFFSNVTWFHAISGTNG - 217
HLA-DRB1*15:01 QDLFLPFFSNVTWFHAIH - 222 -
HLA-DRB1*15:01 FSNVTWFHAIHVSGTNGTKRFD FSNVTWFHAISGTNGTKRFD - 223
HLA-DRB1*15:01 LPFFSNVTWFHAIHVSGTNGT LPFFSNVTWFHAISGTNGT - 239
HLA-DRB1*15:01 PFFSNVTWFHAIHVSGTNGTK PFFSNVTWFHAISGTNGTK - 261
HLA-DRB1*15:01 FFSNVTWFHAIHVSGTNGTKR FFSNVTWFHAISGTNGTKR - 294
HLA-DRB1*15:01 VTWFHAIHVSGTNGTK VTWFHAISGTNGTK 296 -
HLA-DRB1*15:01 FSNVTWFHAIHVSGTNGTKRF FSNVTWFHAISGTNGTKRF - 348
HLA-DRB1*15:01 SNVTWFHAIHVSGTNGTKRFDN SNVTWFHAISGTNGTKRFDN - 364
HLA-DRB1*15:01 NVTWFHAIHVSGTNGTKRFD NVTWFHAISGTNGTKRFD 79 2301
HLA-DRB1*15:01 SNVTWFHAIHVSGTNGTKRF SNVTWFHAISGTNGTKRF 48 1300
HLA-DRB1*15:01 FSNVTWFHAIHVSGTNGTKR FSNVTWFHAISGTNGTKR 38 721
HLA-DRB1*15:01 FFSNVTWFHAIHVSGTNGTK FFSNVTWFHAISGTNGTK 35 589
HLA-DRB1*15:01 VTWFHAIHVSGTNGTKRFDN VTWFHAISGTNGTKRFDN 275 4303
HLA-DRB1*15:01 PFFSNVTWFHAIHVSGTNGT PFFSNVTWFHAISGTNGT 33 515
HLA-DRB1*15:01 LPFFSNVTWFHAIHVSGTNG LPFFSNVTWFHAISGTNG 32 468
HLA-DRB1*15:01 FLPFFSNVTWFHAIHVSGTN FLPFFSNVTWFHAISGTN 31 432
HLA-DRB1*15:01 LFLPFFSNVTWFHAIHVSGT LFLPFFSNVTWFHAISGT 31 413
HLA-DRB1*15:01 DLFLPFFSNVTWFHAIHVSG DLFLPFFSNVTWFHAISG 31 357
HLA-DRB1*15:01 QDLFLPFFSNVTWFHAIHVS QDLFLPFFSNVTWFHAIS 31 225
HLA-DRB1*15:01 FLPFFSNVTWFHAIHVS FLPFFSNVTWFHAIS 32 165
HLA-DRB1*15:01 NVTWFHAIHVSGTNGTKRF NVTWFHAISGTNGTKRF 121 578
HLA-DRB1*15:01 SNVTWFHAIHVSGTNGTKR SNVTWFHAISGTNGTKR 77 342
HLA-DRB1*15:01 LPFFSNVTWFHAIHVSG LPFFSNVTWFHAISG 32 139
HLA-DRB1*15:01 FLPFFSNVTWFHAIHVSGT FLPFFSNVTWFHAISGT 44 172
HLA-DRB1*15:01 FSNVTWFHAIHVSGTNGTK FSNVTWFHAISGTNGTK 53 192
HLA-DRB1*15:01 NVTWFHAIHVSGTNGTK NVTWFHAISGTNGTK 77 272
HLA-DRB1*15:01 LFLPFFSNVTWFHAIHVSG LFLPFFSNVTWFHAISG 47 157
HLA-DRB1*15:01 FFSNVTWFHAIHVSGTNGT FFSNVTWFHAISGTNGT 48 160
HLA-DRB1*15:01 LPFFSNVTWFHAIHVSGTN LPFFSNVTWFHAISGTN 45 142
HLA-DRB1*15:01 PFFSNVTWFHAIHVSGTNG PFFSNVTWFHAISGTNG 46 144
HLA-DRB1*15:01 PFFSNVTWFHAIHVSGT PFFSNVTWFHAISGT 31 88
HLA-DRB1*15:01 SNVTWFHAIHVSGTNGT SNVTWFHAISGTNGT 53 146
HLA-DRB1*15:01 FLPFFSNVTWFHAIHVSG FLPFFSNVTWFHAISG 102 278
HLA-DRB1*15:01 VTWFHAIHVSGTNGTKRFD VTWFHAISGTNGTKRFD 444 1187
HLA-DRB1*15:01 FSNVTWFHAIHVSGTNG FSNVTWFHAISGTNG 33 78
HLA-DRB1*15:01 FFSNVTWFHAIHVSGTN FFSNVTWFHAISGTN 31 69
HLA-DRB1*15:01 LPFFSNVTWFHAIHVSGT LPFFSNVTWFHAISGT 97 214
HLA-DRB1*15:01 DLFLPFFSNVTWFHAIHVS DLFLPFFSNVTWFHAIS 49 107
HLA-DRB1*15:01 NVTWFHAIHVSGTNGTKR NVTWFHAISGTNGTKR 308 642
HLA-DRB1*15:01 LFLPFFSNVTWFHAIHVS LFLPFFSNVTWFHAIS 96 199

T95I

Reference  VSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIV
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    ‑SGTNGTKRFDNPVLPFNDGVYFASIEKSNIIRGWIFGTTLDSKTQSLLIV

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 PFNDGVYFASTEKSNIIRGW PFNDGVYFASIEKSNIIRGW 972 389
HLA-DRB1*15:01 FNDGVYFASTEKSNIIRGWI FNDGVYFASIEKSNIIRGWI 915 370
HLA-DRB1*15:01 LPFNDGVYFASTEKSNIIRG LPFNDGVYFASIEKSNIIRG 937 402
HLA-DRB1*15:01 FNDGVYFASTEKSNI FNDGVYFASIEKSNI 1061 470
HLA-DRB1*15:01 NDGVYFASTEKSNIIRGWIF NDGVYFASIEKSNIIRGWIF 800 367
HLA-DRB1*15:01 DGVYFASTEKSNIIR DGVYFASIEKSNIIR 953 441
HLA-DRB1*15:01 DGVYFASTEKSNIIRGWIFG DGVYFASIEKSNIIRGWIFG 822 383
HLA-DRB1*15:01 VLPFNDGVYFASTEKSNIIR VLPFNDGVYFASIEKSNIIR 811 386
HLA-DRB1*15:01 FASTEKSNIIRGWIF FASIEKSNIIRGWIF 820 391

D950H

Reference  NQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISS
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    NQFNSAIGKIQDSLSSTASALGKLQHVVNQNAQALNTLVKQLSSNFGAISS

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 ALGKLQDVVNQNAQA ALGKLQHVVNQNAQA 1111 165
HLA-DRB1*15:01 SALGKLQDVVNQNAQ SALGKLQHVVNQNAQ 1820 273
HLA-DRB1*15:01 ASALGKLQDVVNQNAQA ASALGKLQHVVNQNAQA 2370 390
HLA-DRB1*15:01 SALGKLQDVVNQNAQA SALGKLQHVVNQNAQA 2153 377
HLA-DRB1*15:01 SALGKLQDVVNQNAQAL SALGKLQHVVNQNAQAL 1450 260
HLA-DRB1*15:01 LGKLQDVVNQNAQAL LGKLQHVVNQNAQAL 678 124
HLA-DRB1*15:01 ALGKLQDVVNQNAQAL ALGKLQHVVNQNAQAL 1359 249
HLA-DRB1*15:01 ALGKLQDVVNQNAQALN ALGKLQHVVNQNAQALN 1265 249
HLA-DRB1*15:01 SSTASALGKLQDVVNQNAQA SSTASALGKLQHVVNQNAQA 1986 402
HLA-DRB1*15:01 TASALGKLQDVVNQNAQAL TASALGKLQHVVNQNAQAL 2042 423
HLA-DRB1*15:01 LGKLQDVVNQNAQALN LGKLQHVVNQNAQALN 1168 250
HLA-DRB1*15:01 LGKLQDVVNQNAQALNT LGKLQHVVNQNAQALNT 1184 262
HLA-DRB1*15:01 STASALGKLQDVVNQNAQAL STASALGKLQHVVNQNAQAL 1192 266
HLA-DRB1*15:01 ASALGKLQDVVNQNAQALN ASALGKLQHVVNQNAQALN 1720 384
HLA-DRB1*15:01 GKLQDVVNQNAQALN GKLQHVVNQNAQALN 703 166
HLA-DRB1*15:01 SALGKLQDVVNQNAQALNT SALGKLQHVVNQNAQALNT 1501 359
HLA-DRB1*15:01 TASALGKLQDVVNQNAQALN TASALGKLQHVVNQNAQALN 907 230
HLA-DRB1*15:01 GKLQDVVNQNAQALNT GKLQHVVNQNAQALNT 1266 348
HLA-DRB1*15:01 ASALGKLQDVVNQNAQALNT ASALGKLQHVVNQNAQALNT 764 212
HLA-DRB1*15:01 ALGKLQDVVNQNAQALNTL ALGKLQHVVNQNAQALNTL 1136 317
HLA-DRB1*15:01 LGKLQDVVNQNAQALNTLV LGKLQHVVNQNAQALNTLV 1164 345
HLA-DRB1*15:01 GKLQDVVNQNAQALNTL GKLQHVVNQNAQALNTL 1025 322
HLA-DRB1*15:01 SALGKLQDVVNQNAQALNTL SALGKLQHVVNQNAQALNTL 550 180
HLA-DRB1*15:01 ALGKLQDVVNQNAQALNTLV ALGKLQHVVNQNAQALNTLV 534 185
HLA-DRB1*15:01 KLQDVVNQNAQALNT KLQHVVNQNAQALNT 714 251
HLA-DRB1*15:01 GKLQDVVNQNAQALNTLVK GKLQHVVNQNAQALNTLVK 1318 478
HLA-DRB1*15:01 LGKLQDVVNQNAQALNTLVK LGKLQHVVNQNAQALNTLVK 526 199
HLA-DRB1*15:01 KLQDVVNQNAQALNTL KLQHVVNQNAQALNTL 1114 432
HLA-DRB1*15:01 KLQDVVNQNAQALNTLV KLQHVVNQNAQALNTLV 1191 493
HLA-DRB1*15:01 GKLQDVVNQNAQALNTLVKQ GKLQHVVNQNAQALNTLVKQ 589 256

NS3 protein

P42L

Reference  QGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKK
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    QGEIKDATPSDFVRATATIPIQASLLFGWLIVGVALLAVFHSASKIITLKK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 TIPIQASLPFGWLIVGVALL TIPIQASLLFGWLIVGVALL 456 1373
HLA-DRB1*15:01 TIPIQASLPFGWLIV TIPIQASLLFGWLIV 198 593
HLA-DRB1*15:01 ATIPIQASLPFGWLIVGVAL ATIPIQASLLFGWLIVGVAL 387 1056
HLA-DRB1*15:01 IPIQASLPFGWLIVG IPIQASLLFGWLIVG 269 726
HLA-DRB1*15:01 ATIPIQASLPFGWLIV ATIPIQASLLFGWLIV 489 1310
HLA-DRB1*15:01 TATIPIQASLPFGWLIVGVA TATIPIQASLLFGWLIVGVA 343 861
HLA-DRB1*15:01 ATATIPIQASLPFGWLIVGV ATATIPIQASLLFGWLIVGV 363 893
HLA-DRB1*15:01 RATATIPIQASLPFGWLIVG RATATIPIQASLLFGWLIVG 381 929
HLA-DRB1*15:01 ATIPIQASLPFGWLIVG ATIPIQASLLFGWLIVG 352 841
HLA-DRB1*15:01 TATIPIQASLPFGWLIV TATIPIQASLLFGWLIV 341 752
HLA-DRB1*15:01 TIPIQASLPFGWLIVGV TIPIQASLLFGWLIVGV 377 781
HLA-DRB1*15:01 VRATATIPIQASLPFGWLIV VRATATIPIQASLLFGWLIV 381 768

Q57H

Reference  TATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCN
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    TATIPIQASLLFGWLIVGVALLAVFHSASKIITLKKRWQLALSKGVHFVCN

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 LIVGVALLAVFQSAS LIVGVALLAVFHSAS 826 393

NS8 protein

T11I

Reference  MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDP
           |||||||||| |||||||||||||||||||||||||
Mutated    MKFLVFLGIIITVAAFHQECSLQSCTQHQPYVVDDP

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 FLVFLGIITTVAAFH FLVFLGIIITVAAFH 375 1133

NSP2 protein

T85I

Reference  WYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEK
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    WYTERSEKSYELQTPFEIKLAKKFDIFNGECPNFVFPLNSIIKTIQPRVEK

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 EIKLAKKFDTFNGECPNFV EIKLAKKFDIFNGECPNFV 926 395
HLA-DRB1*15:01 PFEIKLAKKFDTFNG PFEIKLAKKFDIFNG 189 81
HLA-DRB1*15:01 TPFEIKLAKKFDTFNGEC TPFEIKLAKKFDIFNGEC 1154 498
HLA-DRB1*15:01 ELQTPFEIKLAKKFDTFN ELQTPFEIKLAKKFDIFN 985 431
HLA-DRB1*15:01 PFEIKLAKKFDTFNGECPN PFEIKLAKKFDIFNGECPN 459 201
HLA-DRB1*15:01 QTPFEIKLAKKFDTFNGE QTPFEIKLAKKFDIFNGE 1071 472
HLA-DRB1*15:01 LQTPFEIKLAKKFDTFNG LQTPFEIKLAKKFDIFNG 1072 474
HLA-DRB1*15:01 TPFEIKLAKKFDTFN TPFEIKLAKKFDIFN 162 72
HLA-DRB1*15:01 TPFEIKLAKKFDTFNGECP TPFEIKLAKKFDIFNGECP 421 188
HLA-DRB1*15:01 QTPFEIKLAKKFDTFNGEC QTPFEIKLAKKFDIFNGEC 398 180
HLA-DRB1*15:01 QTPFEIKLAKKFDTFNG QTPFEIKLAKKFDIFNG 285 129
HLA-DRB1*15:01 QTPFEIKLAKKFDTFN QTPFEIKLAKKFDIFN 307 139
HLA-DRB1*15:01 ELQTPFEIKLAKKFDTFNG ELQTPFEIKLAKKFDIFNG 392 178
HLA-DRB1*15:01 PFEIKLAKKFDTFNGEC PFEIKLAKKFDIFNGEC 317 144
HLA-DRB1*15:01 LQTPFEIKLAKKFDTFNGE LQTPFEIKLAKKFDIFNGE 382 175
HLA-DRB1*15:01 TPFEIKLAKKFDTFNGE TPFEIKLAKKFDIFNGE 289 133
HLA-DRB1*15:01 TPFEIKLAKKFDTFNG TPFEIKLAKKFDIFNG 339 157
HLA-DRB1*15:01 FEIKLAKKFDTFNGECPNF FEIKLAKKFDIFNGECPNF 517 240
HLA-DRB1*15:01 PFEIKLAKKFDTFNGE PFEIKLAKKFDIFNGE 357 167
HLA-DRB1*15:01 FEIKLAKKFDTFNGE FEIKLAKKFDIFNGE 192 90
HLA-DRB1*15:01 LQTPFEIKLAKKFDTFN LQTPFEIKLAKKFDIFN 255 120
HLA-DRB1*15:01 EIKLAKKFDTFNGECPN EIKLAKKFDIFNGECPN 616 292
HLA-DRB1*15:01 EIKLAKKFDTFNGEC EIKLAKKFDIFNGEC 354 168
HLA-DRB1*15:01 EIKLAKKFDTFNGECP EIKLAKKFDIFNGECP 725 346
HLA-DRB1*15:01 YELQTPFEIKLAKKFDTF YELQTPFEIKLAKKFDIF 1005 480
HLA-DRB1*15:01 QTPFEIKLAKKFDTF QTPFEIKLAKKFDIF 165 79
HLA-DRB1*15:01 FEIKLAKKFDTFNGEC FEIKLAKKFDIFNGEC 382 183
HLA-DRB1*15:01 EIKLAKKFDTFNGECPNFVF EIKLAKKFDIFNGECPNFVF 458 220
HLA-DRB1*15:01 FEIKLAKKFDTFNGECP FEIKLAKKFDIFNGECP 329 160
HLA-DRB1*15:01 LQTPFEIKLAKKFDTF LQTPFEIKLAKKFDIF 316 154
HLA-DRB1*15:01 LQTPFEIKLAKKFDT LQTPFEIKLAKKFDI 293 143
HLA-DRB1*15:01 PFEIKLAKKFDTFNGECPNF PFEIKLAKKFDIFNGECPNF 225 110
HLA-DRB1*15:01 ELQTPFEIKLAKKFDT ELQTPFEIKLAKKFDI 630 309
HLA-DRB1*15:01 YELQTPFEIKLAKKFDTFN YELQTPFEIKLAKKFDIFN 352 174
HLA-DRB1*15:01 FEIKLAKKFDTFNGECPNFV FEIKLAKKFDIFNGECPNFV 272 135
HLA-DRB1*15:01 LQTPFEIKLAKKFDTFNGEC LQTPFEIKLAKKFDIFNGEC 190 95
HLA-DRB1*15:01 TPFEIKLAKKFDTFNGECPN TPFEIKLAKKFDIFNGECPN 208 104

NSP4 protein

L438P

Reference  EEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSY
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    EEAALCTFLLNKEMYLKLRSDVLLPPTQYNRYLVLYNKYKYFSGAMDTTSY

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Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 SDVLLPLTQYNRYLA SDVLLPPTQYNRYLV 184 1077
HLA-DRB1*15:01 RSDVLLPLTQYNRYLA RSDVLLPPTQYNRYLV 385 2241
HLA-DRB1*15:01 SDVLLPLTQYNRYLAL SDVLLPPTQYNRYLVL 246 1226
HLA-DRB1*15:01 RSDVLLPLTQYNRYL RSDVLLPPTQYNRYL 466 2294
HLA-DRB1*15:01 LRSDVLLPLTQYNRYLA LRSDVLLPPTQYNRYLV 351 1722
HLA-DRB1*15:01 DVLLPLTQYNRYLALY DVLLPPTQYNRYLVLY 203 946
HLA-DRB1*15:01 LKLRSDVLLPLTQYNRYLA LKLRSDVLLPPTQYNRYLV 399 1842
HLA-DRB1*15:01 DVLLPLTQYNRYLAL DVLLPPTQYNRYLVL 119 546
HLA-DRB1*15:01 RSDVLLPLTQYNRYLAL RSDVLLPPTQYNRYLVL 234 1060
HLA-DRB1*15:01 SDVLLPLTQYNRYLALY SDVLLPPTQYNRYLVLY 190 838
HLA-DRB1*15:01 VLLPLTQYNRYLALY VLLPPTQYNRYLVLY 96 419
HLA-DRB1*15:01 KLRSDVLLPLTQYNRYLAL KLRSDVLLPPTQYNRYLVL 313 1354
HLA-DRB1*15:01 SDVLLPLTQYNRYLALYN SDVLLPPTQYNRYLVLYN 445 1800
HLA-DRB1*15:01 VLLPLTQYNRYLALYN VLLPPTQYNRYLVLYN 157 633
HLA-DRB1*15:01 DVLLPLTQYNRYLALYN DVLLPPTQYNRYLVLYN 150 567
HLA-DRB1*15:01 LRSDVLLPLTQYNRYLALY LRSDVLLPPTQYNRYLVLY 273 1031
HLA-DRB1*15:01 LKLRSDVLLPLTQYNRYLAL LKLRSDVLLPPTQYNRYLVL 179 658
HLA-DRB1*15:01 KLRSDVLLPLTQYNRYLALY KLRSDVLLPPTQYNRYLVLY 162 585
HLA-DRB1*15:01 RSDVLLPLTQYNRYLALYN RSDVLLPPTQYNRYLVLYN 205 705
HLA-DRB1*15:01 LLPLTQYNRYLALYN LLPPTQYNRYLVLYN 80 273
HLA-DRB1*15:01 YLKLRSDVLLPLTQYNRYLA YLKLRSDVLLPPTQYNRYLV 188 628
HLA-DRB1*15:01 DVLLPLTQYNRYLALYNK DVLLPPTQYNRYLVLYNK 405 1340
HLA-DRB1*15:01 VLLPLTQYNRYLALYNK VLLPPTQYNRYLVLYNK 131 386
HLA-DRB1*15:01 LRSDVLLPLTQYNRYLALYN LRSDVLLPPTQYNRYLVLYN 123 353
HLA-DRB1*15:01 VLLPLTQYNRYLALYNKY VLLPPTQYNRYLVLYNKY 380 1086
HLA-DRB1*15:01 LLPLTQYNRYLALYNK LLPPTQYNRYLVLYNK 157 447
HLA-DRB1*15:01 SDVLLPLTQYNRYLALYNK SDVLLPPTQYNRYLVLYNK 178 490
HLA-DRB1*15:01 LPLTQYNRYLALYNK LPPTQYNRYLVLYNK 79 208
HLA-DRB1*15:01 RSDVLLPLTQYNRYLALYNK RSDVLLPPTQYNRYLVLYNK 101 250
HLA-DRB1*15:01 LPLTQYNRYLALYNKY LPPTQYNRYLVLYNKY 165 406
HLA-DRB1*15:01 YLKLRSDVLLPLTQYNR YLKLRSDVLLPPTQYNR 443 1090
HLA-DRB1*15:01 DVLLPLTQYNRYLALYNKY DVLLPPTQYNRYLVLYNKY 165 401
HLA-DRB1*15:01 LLPLTQYNRYLALYNKY LLPPTQYNRYLVLYNKY 128 311
HLA-DRB1*15:01 LLPLTQYNRYLALYNKYK LLPPTQYNRYLVLYNKYK 349 838
HLA-DRB1*15:01 PLTQYNRYLALYNKY PPTQYNRYLVLYNKY 84 187
HLA-DRB1*15:01 SDVLLPLTQYNRYLALYNKY SDVLLPPTQYNRYLVLYNKY 96 208
HLA-DRB1*15:01 LPLTQYNRYLALYNKYK LPPTQYNRYLVLYNKYK 117 250
HLA-DRB1*15:01 VLLPLTQYNRYLALYNKYK VLLPPTQYNRYLVLYNKYK 136 287
HLA-DRB1*15:01 YLKLRSDVLLPLTQY YLKLRSDVLLPPTQY 252 514
HLA-DRB1*15:01 KEMYLKLRSDVLLPLTQY KEMYLKLRSDVLLPPTQY 456 919
HLA-DRB1*15:01 PLTQYNRYLALYNKYK PPTQYNRYLVLYNKYK 161 323

A446V

Reference  LLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHL
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    LLNKEMYLKLRSDVLLPPTQYNRYLVLYNKYKYFSGAMDTTSYREAACCHL

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 SDVLLPLTQYNRYLA SDVLLPPTQYNRYLV 184 1077
HLA-DRB1*15:01 RSDVLLPLTQYNRYLA RSDVLLPPTQYNRYLV 385 2241
HLA-DRB1*15:01 SDVLLPLTQYNRYLAL SDVLLPPTQYNRYLVL 246 1226
HLA-DRB1*15:01 LRSDVLLPLTQYNRYLA LRSDVLLPPTQYNRYLV 351 1722
HLA-DRB1*15:01 DVLLPLTQYNRYLALY DVLLPPTQYNRYLVLY 203 946
HLA-DRB1*15:01 LKLRSDVLLPLTQYNRYLA LKLRSDVLLPPTQYNRYLV 399 1842
HLA-DRB1*15:01 DVLLPLTQYNRYLAL DVLLPPTQYNRYLVL 119 546
HLA-DRB1*15:01 RSDVLLPLTQYNRYLAL RSDVLLPPTQYNRYLVL 234 1060
HLA-DRB1*15:01 SDVLLPLTQYNRYLALY SDVLLPPTQYNRYLVLY 190 838
HLA-DRB1*15:01 VLLPLTQYNRYLALY VLLPPTQYNRYLVLY 96 419
HLA-DRB1*15:01 KLRSDVLLPLTQYNRYLAL KLRSDVLLPPTQYNRYLVL 313 1354
HLA-DRB1*15:01 SDVLLPLTQYNRYLALYN SDVLLPPTQYNRYLVLYN 445 1800
HLA-DRB1*15:01 VLLPLTQYNRYLALYN VLLPPTQYNRYLVLYN 157 633
HLA-DRB1*15:01 DVLLPLTQYNRYLALYN DVLLPPTQYNRYLVLYN 150 567
HLA-DRB1*15:01 LRSDVLLPLTQYNRYLALY LRSDVLLPPTQYNRYLVLY 273 1031
HLA-DRB1*15:01 LKLRSDVLLPLTQYNRYLAL LKLRSDVLLPPTQYNRYLVL 179 658
HLA-DRB1*15:01 KLRSDVLLPLTQYNRYLALY KLRSDVLLPPTQYNRYLVLY 162 585
HLA-DRB1*15:01 RSDVLLPLTQYNRYLALYN RSDVLLPPTQYNRYLVLYN 205 705
HLA-DRB1*15:01 LLPLTQYNRYLALYN LLPPTQYNRYLVLYN 80 273
HLA-DRB1*15:01 YLKLRSDVLLPLTQYNRYLA YLKLRSDVLLPPTQYNRYLV 188 628
HLA-DRB1*15:01 DVLLPLTQYNRYLALYNK DVLLPPTQYNRYLVLYNK 405 1340
HLA-DRB1*15:01 VLLPLTQYNRYLALYNK VLLPPTQYNRYLVLYNK 131 386
HLA-DRB1*15:01 LRSDVLLPLTQYNRYLALYN LRSDVLLPPTQYNRYLVLYN 123 353
HLA-DRB1*15:01 VLLPLTQYNRYLALYNKY VLLPPTQYNRYLVLYNKY 380 1086
HLA-DRB1*15:01 LLPLTQYNRYLALYNK LLPPTQYNRYLVLYNK 157 447
HLA-DRB1*15:01 SDVLLPLTQYNRYLALYNK SDVLLPPTQYNRYLVLYNK 178 490
HLA-DRB1*15:01 LPLTQYNRYLALYNK LPPTQYNRYLVLYNK 79 208
HLA-DRB1*15:01 RSDVLLPLTQYNRYLALYNK RSDVLLPPTQYNRYLVLYNK 101 250
HLA-DRB1*15:01 LPLTQYNRYLALYNKY LPPTQYNRYLVLYNKY 165 406
HLA-DRB1*15:01 DVLLPLTQYNRYLALYNKY DVLLPPTQYNRYLVLYNKY 165 401
HLA-DRB1*15:01 LLPLTQYNRYLALYNKY LLPPTQYNRYLVLYNKY 128 311
HLA-DRB1*15:01 LLPLTQYNRYLALYNKYK LLPPTQYNRYLVLYNKYK 349 838
HLA-DRB1*15:01 PLTQYNRYLALYNKY PPTQYNRYLVLYNKY 84 187
HLA-DRB1*15:01 SDVLLPLTQYNRYLALYNKY SDVLLPPTQYNRYLVLYNKY 96 208
HLA-DRB1*15:01 LPLTQYNRYLALYNKYK LPPTQYNRYLVLYNKYK 117 250
HLA-DRB1*15:01 VLLPLTQYNRYLALYNKYK VLLPPTQYNRYLVLYNKYK 136 287
HLA-DRB1*15:01 PLTQYNRYLALYNKYK PPTQYNRYLVLYNKYK 161 323

NSP6 protein

SGF 106-108 deletion

Reference  FNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYD
           |||||||||||||||||||||||||   |||||||||||||||||||||||||
Mutated    FNMVYMPASWVMRIMTWLDMVDTSL‑‑‑KLKDCVMYASAVVLLILMTARTVYD

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 FKLKDCVMYASAVVL KLKDCVMYASAVVL 62 -
HLA-DRB1*15:01 GFKLKDCVMYASAVV KLKDCVMYASAVV 110 -
HLA-DRB1*15:01 GFKLKDCVMYASAVVLL - 117 -
HLA-DRB1*15:01 FKLKDCVMYASAVVLLI - 125 -
HLA-DRB1*15:01 SGFKLKDCVMYASAVVL KLKDCVMYASAVVL 126 -
HLA-DRB1*15:01 FKLKDCVMYASAVVLL - 163 -
HLA-DRB1*15:01 GFKLKDCVMYASAVVL KLKDCVMYASAVVL 171 -
HLA-DRB1*15:01 MVDTSLSGFKLKDCVMYASAVVL MVDTSLKLKDCVMYASAVVL - 195
HLA-DRB1*15:01 VDTSLSGFKLKDCVMYASAVVLL VDTSLKLKDCVMYASAVVLL - 204
HLA-DRB1*15:01 LSGFKLKDCVMYASAVV LKLKDCVMYASAVV 217 -
HLA-DRB1*15:01 DTSLSGFKLKDCVMYASAVVLLI DTSLKLKDCVMYASAVVLLI - 224
HLA-DRB1*15:01 TSLSGFKLKDCVMYASAVVLLIL TSLKLKDCVMYASAVVLLIL - 231
HLA-DRB1*15:01 SGFKLKDCVMYASAVVLLIL - 239 -
HLA-DRB1*15:01 SLSGFKLKDCVMYASAVVLLILM SLKLKDCVMYASAVVLLILM - 252
HLA-DRB1*15:01 GFKLKDCVMYASAVVLLILM - 253 -
HLA-DRB1*15:01 DMVDTSLSGFKLKDCVMYASAVV DMVDTSLKLKDCVMYASAVV - 264
HLA-DRB1*15:01 FKLKDCVMYASAVVLLILMT - 276 -
HLA-DRB1*15:01 LSGFKLKDCVMYASAVVLLILMT LKLKDCVMYASAVVLLILMT - 282
HLA-DRB1*15:01 SGFKLKDCVMYASAVV KLKDCVMYASAVV 285 -
HLA-DRB1*15:01 VDTSLSGFKLKDCVMYASAVVL VDTSLKLKDCVMYASAVVL - 295
HLA-DRB1*15:01 DTSLSGFKLKDCVMYASAVVLL DTSLKLKDCVMYASAVVLL - 296
HLA-DRB1*15:01 SGFKLKDCVMYASAVVLLI - 314 -
HLA-DRB1*15:01 TSLSGFKLKDCVMYASAVVLLI TSLKLKDCVMYASAVVLLI - 319
HLA-DRB1*15:01 GFKLKDCVMYASAVVLLIL - 333 -
HLA-DRB1*15:01 SLSGFKLKDCVMYASAVVLLIL SLKLKDCVMYASAVVLLIL - 335
HLA-DRB1*15:01 FKLKDCVMYASAVVLLILM - 358 -
HLA-DRB1*15:01 LSGFKLKDCVMYASAVVLLILM LKLKDCVMYASAVVLLILM - 361
HLA-DRB1*15:01 MRIMTWLDMVDTSLS MRIMTWLDMVDTSL 382 -
HLA-DRB1*15:01 SWVMRIMTWLDMVDTSLSGFKLK SWVMRIMTWLDMVDTSLKLK - 401
HLA-DRB1*15:01 MVDTSLSGFKLKDCVMYASAVV MVDTSLKLKDCVMYASAVV - 441
HLA-DRB1*15:01 ASWVMRIMTWLDMVDTSLSGFKL ASWVMRIMTWLDMVDTSLKL - 459
HLA-DRB1*15:01 WVMRIMTWLDMVDTSLSGFKLKD WVMRIMTWLDMVDTSLKLKD - 466
HLA-DRB1*15:01 LSGFKLKDCVMYASAVVL LKLKDCVMYASAVVL 630 61
HLA-DRB1*15:01 SLSGFKLKDCVMYASAVV SLKLKDCVMYASAVV 1025 108
HLA-DRB1*15:01 MRIMTWLDMVDTSLSGFK MRIMTWLDMVDTSLK 2429 340

NSP12 protein

P323L

Reference  CVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    CVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHF

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DRB1*15:01 FSTVFPPTSFGPLVRK FSTVFPLTSFGPLVRK 2472 145
HLA-DRB1*15:01 STVFPPTSFGPLVRK STVFPLTSFGPLVRK 1187 73
HLA-DRB1*15:01 FSTVFPPTSFGPLVR FSTVFPLTSFGPLVR 1497 93
HLA-DRB1*15:01 STVFPPTSFGPLVRKI STVFPLTSFGPLVRKI 1911 131
HLA-DRB1*15:01 FSTVFPPTSFGPLVRKI FSTVFPLTSFGPLVRKI 1398 104
HLA-DRB1*15:01 TVFPPTSFGPLVRKI TVFPLTSFGPLVRKI 819 65
HLA-DRB1*15:01 LFSTVFPPTSFGPLVRKI LFSTVFPLTSFGPLVRKI 4430 355
HLA-DRB1*15:01 FSTVFPPTSFGPLVRKIF FSTVFPLTSFGPLVRKIF 3238 268
HLA-DRB1*15:01 LFSTVFPPTSFGPLVRK LFSTVFPLTSFGPLVRK 1458 125
HLA-DRB1*15:01 LFSTVFPPTSFGPLVR LFSTVFPLTSFGPLVR 2515 220
HLA-DRB1*15:01 TVFPPTSFGPLVRKIF TVFPLTSFGPLVRKIF 1138 110
HLA-DRB1*15:01 TVFPPTSFGPLVRKIFVD TVFPLTSFGPLVRKIFVD 3046 300
HLA-DRB1*15:01 STVFPPTSFGPLVRKIFV STVFPLTSFGPLVRKIFV 2782 277
HLA-DRB1*15:01 STVFPPTSFGPLVRKIF STVFPLTSFGPLVRKIF 895 92
HLA-DRB1*15:01 VFPPTSFGPLVRKIFVDG VFPLTSFGPLVRKIFVDG 3100 329
HLA-DRB1*15:01 VLFSTVFPPTSFGPLVRK VLFSTVFPLTSFGPLVRK 4258 469
HLA-DRB1*15:01 VFPPTSFGPLVRKIFV VFPLTSFGPLVRKIFV 1011 116
HLA-DRB1*15:01 LFSTVFPPTSFGPLVRKIF LFSTVFPLTSFGPLVRKIF 1264 147
HLA-DRB1*15:01 VFPPTSFGPLVRKIF VFPLTSFGPLVRKIF 482 57
HLA-DRB1*15:01 FPPTSFGPLVRKIFVD FPLTSFGPLVRKIFVD 1393 165
HLA-DRB1*15:01 VLFSTVFPPTSFGPLVRKI VLFSTVFPLTSFGPLVRKI 1477 177
HLA-DRB1*15:01 TVFPPTSFGPLVRKIFV TVFPLTSFGPLVRKIFV 774 96
HLA-DRB1*15:01 VFPPTSFGPLVRKIFVD VFPLTSFGPLVRKIFVD 857 108
HLA-DRB1*15:01 STVFPPTSFGPLVRKIFVD STVFPLTSFGPLVRKIFVD 1234 160
HLA-DRB1*15:01 FSTVFPPTSFGPLVRKIFV FSTVFPLTSFGPLVRKIFV 1114 146
HLA-DRB1*15:01 FPPTSFGPLVRKIFV FPLTSFGPLVRKIFV 551 76
HLA-DRB1*15:01 NVLFSTVFPPTSFGPLVRK NVLFSTVFPLTSFGPLVRK 1483 205
HLA-DRB1*15:01 FSTVFPPTSFGPLVRKIFVD FSTVFPLTSFGPLVRKIFVD 670 94
HLA-DRB1*15:01 TVFPPTSFGPLVRKIFVDG TVFPLTSFGPLVRKIFVDG 1261 177
HLA-DRB1*15:01 VLFSTVFPPTSFGPLVR VLFSTVFPLTSFGPLVR 1281 180
HLA-DRB1*15:01 FPPTSFGPLVRKIFVDG FPLTSFGPLVRKIFVDG 1102 155
HLA-DRB1*15:01 STVFPPTSFGPLVRKIFVDG STVFPLTSFGPLVRKIFVDG 705 100
HLA-DRB1*15:01 NVLFSTVFPPTSFGPLVRKI NVLFSTVFPLTSFGPLVRKI 700 102
HLA-DRB1*15:01 FPPTSFGPLVRKIFVDGV FPLTSFGPLVRKIFVDGV 3306 483
HLA-DRB1*15:01 VLFSTVFPPTSFGPLVRKIF VLFSTVFPLTSFGPLVRKIF 595 89
HLA-DRB1*15:01 LFSTVFPPTSFGPLVRKIFV LFSTVFPLTSFGPLVRKIFV 593 91
HLA-DRB1*15:01 PPTSFGPLVRKIFVDG PLTSFGPLVRKIFVDG 1963 311
HLA-DRB1*15:01 PPTSFGPLVRKIFVD PLTSFGPLVRKIFVD 902 143
HLA-DRB1*15:01 VFPPTSFGPLVRKIFVDGV VFPLTSFGPLVRKIFVDGV 1195 195
HLA-DRB1*15:01 TVFPPTSFGPLVRKIFVDGV TVFPLTSFGPLVRKIFVDGV 654 110
HLA-DRB1*15:01 VFPPTSFGPLVRKIFVDGVP VFPLTSFGPLVRKIFVDGVP 656 125
HLA-DRB1*15:01 LFSTVFPPTSFGPLV LFSTVFPLTSFGPLV 1566 306
HLA-DRB1*15:01 FNVLFSTVFPPTSFGPLVRK FNVLFSTVFPLTSFGPLVRK 615 122
HLA-DRB1*15:01 FPPTSFGPLVRKIFVDGVP FPLTSFGPLVRKIFVDGVP 1393 282
HLA-DRB1*15:01 PPTSFGPLVRKIFVDGV PLTSFGPLVRKIFVDGV 1259 277
HLA-DRB1*15:01 FNVLFSTVFPPTSFGPLVR FNVLFSTVFPLTSFGPLVR 1227 303
HLA-DRB1*15:01 ANFNVLFSTVFPPTS ANFNVLFSTVFPLTS 287 72
HLA-DRB1*15:01 HCANFNVLFSTVFPPTS HCANFNVLFSTVFPLTS 664 176
HLA-DRB1*15:01 NVLFSTVFPPTSFGPLV NVLFSTVFPLTSFGPLV 1293 348
HLA-DRB1*15:01 CANFNVLFSTVFPPTS CANFNVLFSTVFPLTS 873 236
HLA-DRB1*15:01 CANFNVLFSTVFPPT CANFNVLFSTVFPLT 400 110
HLA-DRB1*15:01 NFNVLFSTVFPPTSF NFNVLFSTVFPLTSF 272 78
HLA-DRB1*15:01 NVLFSTVFPPTSFGP NVLFSTVFPLTSFGP 674 198
HLA-DRB1*15:01 NFNVLFSTVFPPTSFGPLVR NFNVLFSTVFPLTSFGPLVR 571 168
HLA-DRB1*15:01 NVLFSTVFPPTSFGPL NVLFSTVFPLTSFGPL 1664 493
HLA-DRB1*15:01 FPPTSFGPLVRKIFVDGVPF FPLTSFGPLVRKIFVDGVPF 591 177
HLA-DRB1*15:01 HCANFNVLFSTVFPP HCANFNVLFSTVFPL 654 209
HLA-DRB1*15:01 NFNVLFSTVFPPTSFGP NFNVLFSTVFPLTSFGP 610 195
HLA-DRB1*15:01 LHCANFNVLFSTVFPPT LHCANFNVLFSTVFPLT 801 261
HLA-DRB1*15:01 NFNVLFSTVFPPTSFG NFNVLFSTVFPLTSFG 778 256
HLA-DRB1*15:01 CANFNVLFSTVFPPTSF CANFNVLFSTVFPLTSF 516 170
HLA-DRB1*15:01 PTSFGPLVRKIFVDG LTSFGPLVRKIFVDG 1116 369
HLA-DRB1*15:01 HCANFNVLFSTVFPPT HCANFNVLFSTVFPLT 1018 341
HLA-DRB1*15:01 ANFNVLFSTVFPPTSFG ANFNVLFSTVFPLTSFG 519 177
HLA-DRB1*15:01 ANFNVLFSTVFPPTSF ANFNVLFSTVFPLTSF 645 228
HLA-DRB1*15:01 FNVLFSTVFPPTSFG FNVLFSTVFPLTSFG 381 139
HLA-DRB1*15:01 VLFSTVFPPTSFGPL VLFSTVFPLTSFGPL 860 324
HLA-DRB1*15:01 FNVLFSTVFPPTSFGPL FNVLFSTVFPLTSFGPL 784 296
HLA-DRB1*15:01 PPTSFGPLVRKIFVDGVPF PLTSFGPLVRKIFVDGVPF 1177 454
HLA-DRB1*15:01 FNVLFSTVFPPTSFGP FNVLFSTVFPLTSFGP 1032 415
HLA-DRB1*15:01 NFNVLFSTVFPPTSFGPLV NFNVLFSTVFPLTSFGPLV 1075 460
HLA-DRB1*15:01 ILHCANFNVLFSTVFPP ILHCANFNVLFSTVFPL 866 387
HLA-DRB1*15:01 ILHCANFNVLFSTVFPPTS ILHCANFNVLFSTVFPLTS 912 424
HLA-DRB1*15:01 ANFNVLFSTVFPPTSFGPL ANFNVLFSTVFPLTSFGPL 955 453
HLA-DRB1*15:01 CANFNVLFSTVFPPTSFGP CANFNVLFSTVFPLTSFGP 950 474