This strain contains 20 protein-level mutations:
We identified all possible linear viral peptides affected by these mutations. Whenever it was possible, we matched the reference peptide with the mutated one. For example, D -> L mutation transformed SDNGPQNQR to SLNGPQNQR. Cases when it was not meaningful included deletions and insertions at the flanks of the peptide, e.g., HV deletion in NVTWFHAIHV peptide.
Then, we predicted binding affinities between the selected peptides and frequent HLA alleles. Predictions were made with NetMHCpan-4.1 and NetMHCIIpan-4.0. The binding affinities were classifies into three groups:
Here we report HLA-peptide interactions whose affinity was altered by at least two folds. Note that mutations with empty set of altered interactions are not showed.
Weaker binding was found for 164 epitopes, while stronger binding was found for 191 entries. There are 916 tight binders for the HLA-DRB1*15:01 in the reference immunopeptidome (IC50 affinity ≤ 50 nM); 32 of them became non-tight binders (3.5%) and 0 novel tight binders appeared (0.0%). To avoid possible divisions by zero, we used + 1 regularization term in denominators when calculating percentages.
Reference RSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFAST
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Mutated RSSVLHSTQDLFLPFFSNVTWFHAI‑‑SGTNGTKRFDNPVLPFNDGVYFASI
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | PFFSNVTWFHAIHVS | PFFSNVTWFHAIS | 19 | - |
HLA-DRB1*15:01 | FFSNVTWFHAIHVSG | FFSNVTWFHAISG | 19 | - |
HLA-DRB1*15:01 | FSNVTWFHAIHVSGT | FSNVTWFHAISGT | 19 | - |
HLA-DRB1*15:01 | SNVTWFHAIHVSGTN | SNVTWFHAISGTN | 26 | - |
HLA-DRB1*15:01 | LPFFSNVTWFHAIHV | LPFFSNVTWFHAI | 30 | - |
HLA-DRB1*15:01 | FFSNVTWFHAIHVSGT | FFSNVTWFHAISGT | 35 | - |
HLA-DRB1*15:01 | PFFSNVTWFHAIHVSG | PFFSNVTWFHAISG | 36 | - |
HLA-DRB1*15:01 | LPFFSNVTWFHAIHVS | LPFFSNVTWFHAIS | 37 | - |
HLA-DRB1*15:01 | FSNVTWFHAIHVSGTN | FSNVTWFHAISGTN | 37 | - |
HLA-DRB1*15:01 | NVTWFHAIHVSGTNG | NVTWFHAISGTNG | 37 | - |
HLA-DRB1*15:01 | TQDLFLPFFSNVTWFHAIHV | - | 43 | - |
HLA-DRB1*15:01 | LFLPFFSNVTWFHAIHV | - | 50 | - |
HLA-DRB1*15:01 | SNVTWFHAIHVSGTNG | SNVTWFHAISGTNG | 57 | - |
HLA-DRB1*15:01 | FLPFFSNVTWFHAIHV | FLPFFSNVTWFHAI | 60 | - |
HLA-DRB1*15:01 | QDLFLPFFSNVTWFHAIHV | - | 64 | - |
HLA-DRB1*15:01 | STQDLFLPFFSNVTWFHAIH | - | 72 | - |
HLA-DRB1*15:01 | STQDLFLPFFSNVTWFHAIHVS | STQDLFLPFFSNVTWFHAIS | - | 73 |
HLA-DRB1*15:01 | TQDLFLPFFSNVTWFHAIHVSG | TQDLFLPFFSNVTWFHAISG | - | 76 |
HLA-DRB1*15:01 | QDLFLPFFSNVTWFHAIHVSGT | QDLFLPFFSNVTWFHAISGT | - | 81 |
HLA-DRB1*15:01 | NVTWFHAIHVSGTNGT | NVTWFHAISGTNGT | 81 | - |
HLA-DRB1*15:01 | DLFLPFFSNVTWFHAIHVSGTN | DLFLPFFSNVTWFHAISGTN | - | 101 |
HLA-DRB1*15:01 | DLFLPFFSNVTWFHAIH | - | 104 | - |
HLA-DRB1*15:01 | TQDLFLPFFSNVTWFHAIH | - | 111 | - |
HLA-DRB1*15:01 | TQDLFLPFFSNVTWFHAIHVS | TQDLFLPFFSNVTWFHAIS | - | 112 |
HLA-DRB1*15:01 | LFLPFFSNVTWFHAIHVSGTNG | LFLPFFSNVTWFHAISGTNG | - | 117 |
HLA-DRB1*15:01 | VTWFHAIHVSGTNGT | VTWFHAISGTNGT | 123 | - |
HLA-DRB1*15:01 | QDLFLPFFSNVTWFHAIHVSG | QDLFLPFFSNVTWFHAISG | - | 124 |
HLA-DRB1*15:01 | DLFLPFFSNVTWFHAIHV | - | 135 | - |
HLA-DRB1*15:01 | FLPFFSNVTWFHAIHVSGTNGT | FLPFFSNVTWFHAISGTNGT | - | 137 |
HLA-DRB1*15:01 | LPFFSNVTWFHAIHVSGTNGTK | LPFFSNVTWFHAISGTNGTK | - | 150 |
HLA-DRB1*15:01 | FLPFFSNVTWFHAIH | FLPFFSNVTWFHAI | 155 | - |
HLA-DRB1*15:01 | PFFSNVTWFHAIHVSGTNGTKR | PFFSNVTWFHAISGTNGTKR | - | 156 |
HLA-DRB1*15:01 | DLFLPFFSNVTWFHAIHVSGT | DLFLPFFSNVTWFHAISGT | - | 178 |
HLA-DRB1*15:01 | FFSNVTWFHAIHVSGTNGTKRF | FFSNVTWFHAISGTNGTKRF | - | 182 |
HLA-DRB1*15:01 | LFLPFFSNVTWFHAIH | - | 191 | - |
HLA-DRB1*15:01 | LFLPFFSNVTWFHAIHVSGTN | LFLPFFSNVTWFHAISGTN | - | 192 |
HLA-DRB1*15:01 | FLPFFSNVTWFHAIHVSGTNG | FLPFFSNVTWFHAISGTNG | - | 217 |
HLA-DRB1*15:01 | QDLFLPFFSNVTWFHAIH | - | 222 | - |
HLA-DRB1*15:01 | FSNVTWFHAIHVSGTNGTKRFD | FSNVTWFHAISGTNGTKRFD | - | 223 |
HLA-DRB1*15:01 | LPFFSNVTWFHAIHVSGTNGT | LPFFSNVTWFHAISGTNGT | - | 239 |
HLA-DRB1*15:01 | PFFSNVTWFHAIHVSGTNGTK | PFFSNVTWFHAISGTNGTK | - | 261 |
HLA-DRB1*15:01 | FFSNVTWFHAIHVSGTNGTKR | FFSNVTWFHAISGTNGTKR | - | 294 |
HLA-DRB1*15:01 | VTWFHAIHVSGTNGTK | VTWFHAISGTNGTK | 296 | - |
HLA-DRB1*15:01 | FSNVTWFHAIHVSGTNGTKRF | FSNVTWFHAISGTNGTKRF | - | 348 |
HLA-DRB1*15:01 | SNVTWFHAIHVSGTNGTKRFDN | SNVTWFHAISGTNGTKRFDN | - | 364 |
HLA-DRB1*15:01 | NVTWFHAIHVSGTNGTKRFD | NVTWFHAISGTNGTKRFD | 79 | 2301 |
HLA-DRB1*15:01 | SNVTWFHAIHVSGTNGTKRF | SNVTWFHAISGTNGTKRF | 48 | 1300 |
HLA-DRB1*15:01 | FSNVTWFHAIHVSGTNGTKR | FSNVTWFHAISGTNGTKR | 38 | 721 |
HLA-DRB1*15:01 | FFSNVTWFHAIHVSGTNGTK | FFSNVTWFHAISGTNGTK | 35 | 589 |
HLA-DRB1*15:01 | VTWFHAIHVSGTNGTKRFDN | VTWFHAISGTNGTKRFDN | 275 | 4303 |
HLA-DRB1*15:01 | PFFSNVTWFHAIHVSGTNGT | PFFSNVTWFHAISGTNGT | 33 | 515 |
HLA-DRB1*15:01 | LPFFSNVTWFHAIHVSGTNG | LPFFSNVTWFHAISGTNG | 32 | 468 |
HLA-DRB1*15:01 | FLPFFSNVTWFHAIHVSGTN | FLPFFSNVTWFHAISGTN | 31 | 432 |
HLA-DRB1*15:01 | LFLPFFSNVTWFHAIHVSGT | LFLPFFSNVTWFHAISGT | 31 | 413 |
HLA-DRB1*15:01 | DLFLPFFSNVTWFHAIHVSG | DLFLPFFSNVTWFHAISG | 31 | 357 |
HLA-DRB1*15:01 | QDLFLPFFSNVTWFHAIHVS | QDLFLPFFSNVTWFHAIS | 31 | 225 |
HLA-DRB1*15:01 | FLPFFSNVTWFHAIHVS | FLPFFSNVTWFHAIS | 32 | 165 |
HLA-DRB1*15:01 | NVTWFHAIHVSGTNGTKRF | NVTWFHAISGTNGTKRF | 121 | 578 |
HLA-DRB1*15:01 | SNVTWFHAIHVSGTNGTKR | SNVTWFHAISGTNGTKR | 77 | 342 |
HLA-DRB1*15:01 | LPFFSNVTWFHAIHVSG | LPFFSNVTWFHAISG | 32 | 139 |
HLA-DRB1*15:01 | FLPFFSNVTWFHAIHVSGT | FLPFFSNVTWFHAISGT | 44 | 172 |
HLA-DRB1*15:01 | FSNVTWFHAIHVSGTNGTK | FSNVTWFHAISGTNGTK | 53 | 192 |
HLA-DRB1*15:01 | NVTWFHAIHVSGTNGTK | NVTWFHAISGTNGTK | 77 | 272 |
HLA-DRB1*15:01 | LFLPFFSNVTWFHAIHVSG | LFLPFFSNVTWFHAISG | 47 | 157 |
HLA-DRB1*15:01 | FFSNVTWFHAIHVSGTNGT | FFSNVTWFHAISGTNGT | 48 | 160 |
HLA-DRB1*15:01 | LPFFSNVTWFHAIHVSGTN | LPFFSNVTWFHAISGTN | 45 | 142 |
HLA-DRB1*15:01 | PFFSNVTWFHAIHVSGTNG | PFFSNVTWFHAISGTNG | 46 | 144 |
HLA-DRB1*15:01 | PFFSNVTWFHAIHVSGT | PFFSNVTWFHAISGT | 31 | 88 |
HLA-DRB1*15:01 | SNVTWFHAIHVSGTNGT | SNVTWFHAISGTNGT | 53 | 146 |
HLA-DRB1*15:01 | FLPFFSNVTWFHAIHVSG | FLPFFSNVTWFHAISG | 102 | 278 |
HLA-DRB1*15:01 | VTWFHAIHVSGTNGTKRFD | VTWFHAISGTNGTKRFD | 444 | 1187 |
HLA-DRB1*15:01 | FSNVTWFHAIHVSGTNG | FSNVTWFHAISGTNG | 33 | 78 |
HLA-DRB1*15:01 | FFSNVTWFHAIHVSGTN | FFSNVTWFHAISGTN | 31 | 69 |
HLA-DRB1*15:01 | LPFFSNVTWFHAIHVSGT | LPFFSNVTWFHAISGT | 97 | 214 |
HLA-DRB1*15:01 | DLFLPFFSNVTWFHAIHVS | DLFLPFFSNVTWFHAIS | 49 | 107 |
HLA-DRB1*15:01 | NVTWFHAIHVSGTNGTKR | NVTWFHAISGTNGTKR | 308 | 642 |
HLA-DRB1*15:01 | LFLPFFSNVTWFHAIHVS | LFLPFFSNVTWFHAIS | 96 | 199 |
Reference VSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIV
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Mutated ‑SGTNGTKRFDNPVLPFNDGVYFASIEKSNIIRGWIFGTTLDSKTQSLLIV
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | PFNDGVYFASTEKSNIIRGW | PFNDGVYFASIEKSNIIRGW | 972 | 389 |
HLA-DRB1*15:01 | FNDGVYFASTEKSNIIRGWI | FNDGVYFASIEKSNIIRGWI | 915 | 370 |
HLA-DRB1*15:01 | LPFNDGVYFASTEKSNIIRG | LPFNDGVYFASIEKSNIIRG | 937 | 402 |
HLA-DRB1*15:01 | FNDGVYFASTEKSNI | FNDGVYFASIEKSNI | 1061 | 470 |
HLA-DRB1*15:01 | NDGVYFASTEKSNIIRGWIF | NDGVYFASIEKSNIIRGWIF | 800 | 367 |
HLA-DRB1*15:01 | DGVYFASTEKSNIIR | DGVYFASIEKSNIIR | 953 | 441 |
HLA-DRB1*15:01 | DGVYFASTEKSNIIRGWIFG | DGVYFASIEKSNIIRGWIFG | 822 | 383 |
HLA-DRB1*15:01 | VLPFNDGVYFASTEKSNIIR | VLPFNDGVYFASIEKSNIIR | 811 | 386 |
HLA-DRB1*15:01 | FASTEKSNIIRGWIF | FASIEKSNIIRGWIF | 820 | 391 |
Reference NQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISS
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Mutated NQFNSAIGKIQDSLSSTASALGKLQHVVNQNAQALNTLVKQLSSNFGAISS
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | ALGKLQDVVNQNAQA | ALGKLQHVVNQNAQA | 1111 | 165 |
HLA-DRB1*15:01 | SALGKLQDVVNQNAQ | SALGKLQHVVNQNAQ | 1820 | 273 |
HLA-DRB1*15:01 | ASALGKLQDVVNQNAQA | ASALGKLQHVVNQNAQA | 2370 | 390 |
HLA-DRB1*15:01 | SALGKLQDVVNQNAQA | SALGKLQHVVNQNAQA | 2153 | 377 |
HLA-DRB1*15:01 | SALGKLQDVVNQNAQAL | SALGKLQHVVNQNAQAL | 1450 | 260 |
HLA-DRB1*15:01 | LGKLQDVVNQNAQAL | LGKLQHVVNQNAQAL | 678 | 124 |
HLA-DRB1*15:01 | ALGKLQDVVNQNAQAL | ALGKLQHVVNQNAQAL | 1359 | 249 |
HLA-DRB1*15:01 | ALGKLQDVVNQNAQALN | ALGKLQHVVNQNAQALN | 1265 | 249 |
HLA-DRB1*15:01 | SSTASALGKLQDVVNQNAQA | SSTASALGKLQHVVNQNAQA | 1986 | 402 |
HLA-DRB1*15:01 | TASALGKLQDVVNQNAQAL | TASALGKLQHVVNQNAQAL | 2042 | 423 |
HLA-DRB1*15:01 | LGKLQDVVNQNAQALN | LGKLQHVVNQNAQALN | 1168 | 250 |
HLA-DRB1*15:01 | LGKLQDVVNQNAQALNT | LGKLQHVVNQNAQALNT | 1184 | 262 |
HLA-DRB1*15:01 | STASALGKLQDVVNQNAQAL | STASALGKLQHVVNQNAQAL | 1192 | 266 |
HLA-DRB1*15:01 | ASALGKLQDVVNQNAQALN | ASALGKLQHVVNQNAQALN | 1720 | 384 |
HLA-DRB1*15:01 | GKLQDVVNQNAQALN | GKLQHVVNQNAQALN | 703 | 166 |
HLA-DRB1*15:01 | SALGKLQDVVNQNAQALNT | SALGKLQHVVNQNAQALNT | 1501 | 359 |
HLA-DRB1*15:01 | TASALGKLQDVVNQNAQALN | TASALGKLQHVVNQNAQALN | 907 | 230 |
HLA-DRB1*15:01 | GKLQDVVNQNAQALNT | GKLQHVVNQNAQALNT | 1266 | 348 |
HLA-DRB1*15:01 | ASALGKLQDVVNQNAQALNT | ASALGKLQHVVNQNAQALNT | 764 | 212 |
HLA-DRB1*15:01 | ALGKLQDVVNQNAQALNTL | ALGKLQHVVNQNAQALNTL | 1136 | 317 |
HLA-DRB1*15:01 | LGKLQDVVNQNAQALNTLV | LGKLQHVVNQNAQALNTLV | 1164 | 345 |
HLA-DRB1*15:01 | GKLQDVVNQNAQALNTL | GKLQHVVNQNAQALNTL | 1025 | 322 |
HLA-DRB1*15:01 | SALGKLQDVVNQNAQALNTL | SALGKLQHVVNQNAQALNTL | 550 | 180 |
HLA-DRB1*15:01 | ALGKLQDVVNQNAQALNTLV | ALGKLQHVVNQNAQALNTLV | 534 | 185 |
HLA-DRB1*15:01 | KLQDVVNQNAQALNT | KLQHVVNQNAQALNT | 714 | 251 |
HLA-DRB1*15:01 | GKLQDVVNQNAQALNTLVK | GKLQHVVNQNAQALNTLVK | 1318 | 478 |
HLA-DRB1*15:01 | LGKLQDVVNQNAQALNTLVK | LGKLQHVVNQNAQALNTLVK | 526 | 199 |
HLA-DRB1*15:01 | KLQDVVNQNAQALNTL | KLQHVVNQNAQALNTL | 1114 | 432 |
HLA-DRB1*15:01 | KLQDVVNQNAQALNTLV | KLQHVVNQNAQALNTLV | 1191 | 493 |
HLA-DRB1*15:01 | GKLQDVVNQNAQALNTLVKQ | GKLQHVVNQNAQALNTLVKQ | 589 | 256 |
Reference QGEIKDATPSDFVRATATIPIQASLPFGWLIVGVALLAVFQSASKIITLKK
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Mutated QGEIKDATPSDFVRATATIPIQASLLFGWLIVGVALLAVFHSASKIITLKK
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | TIPIQASLPFGWLIVGVALL | TIPIQASLLFGWLIVGVALL | 456 | 1373 |
HLA-DRB1*15:01 | TIPIQASLPFGWLIV | TIPIQASLLFGWLIV | 198 | 593 |
HLA-DRB1*15:01 | ATIPIQASLPFGWLIVGVAL | ATIPIQASLLFGWLIVGVAL | 387 | 1056 |
HLA-DRB1*15:01 | IPIQASLPFGWLIVG | IPIQASLLFGWLIVG | 269 | 726 |
HLA-DRB1*15:01 | ATIPIQASLPFGWLIV | ATIPIQASLLFGWLIV | 489 | 1310 |
HLA-DRB1*15:01 | TATIPIQASLPFGWLIVGVA | TATIPIQASLLFGWLIVGVA | 343 | 861 |
HLA-DRB1*15:01 | ATATIPIQASLPFGWLIVGV | ATATIPIQASLLFGWLIVGV | 363 | 893 |
HLA-DRB1*15:01 | RATATIPIQASLPFGWLIVG | RATATIPIQASLLFGWLIVG | 381 | 929 |
HLA-DRB1*15:01 | ATIPIQASLPFGWLIVG | ATIPIQASLLFGWLIVG | 352 | 841 |
HLA-DRB1*15:01 | TATIPIQASLPFGWLIV | TATIPIQASLLFGWLIV | 341 | 752 |
HLA-DRB1*15:01 | TIPIQASLPFGWLIVGV | TIPIQASLLFGWLIVGV | 377 | 781 |
HLA-DRB1*15:01 | VRATATIPIQASLPFGWLIV | VRATATIPIQASLLFGWLIV | 381 | 768 |
Reference TATIPIQASLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCN
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Mutated TATIPIQASLLFGWLIVGVALLAVFHSASKIITLKKRWQLALSKGVHFVCN
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | LIVGVALLAVFQSAS | LIVGVALLAVFHSAS | 826 | 393 |
Reference MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDP
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Mutated MKFLVFLGIIITVAAFHQECSLQSCTQHQPYVVDDP
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | FLVFLGIITTVAAFH | FLVFLGIIITVAAFH | 375 | 1133 |
Reference WYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEK
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Mutated WYTERSEKSYELQTPFEIKLAKKFDIFNGECPNFVFPLNSIIKTIQPRVEK
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | EIKLAKKFDTFNGECPNFV | EIKLAKKFDIFNGECPNFV | 926 | 395 |
HLA-DRB1*15:01 | PFEIKLAKKFDTFNG | PFEIKLAKKFDIFNG | 189 | 81 |
HLA-DRB1*15:01 | TPFEIKLAKKFDTFNGEC | TPFEIKLAKKFDIFNGEC | 1154 | 498 |
HLA-DRB1*15:01 | ELQTPFEIKLAKKFDTFN | ELQTPFEIKLAKKFDIFN | 985 | 431 |
HLA-DRB1*15:01 | PFEIKLAKKFDTFNGECPN | PFEIKLAKKFDIFNGECPN | 459 | 201 |
HLA-DRB1*15:01 | QTPFEIKLAKKFDTFNGE | QTPFEIKLAKKFDIFNGE | 1071 | 472 |
HLA-DRB1*15:01 | LQTPFEIKLAKKFDTFNG | LQTPFEIKLAKKFDIFNG | 1072 | 474 |
HLA-DRB1*15:01 | TPFEIKLAKKFDTFN | TPFEIKLAKKFDIFN | 162 | 72 |
HLA-DRB1*15:01 | TPFEIKLAKKFDTFNGECP | TPFEIKLAKKFDIFNGECP | 421 | 188 |
HLA-DRB1*15:01 | QTPFEIKLAKKFDTFNGEC | QTPFEIKLAKKFDIFNGEC | 398 | 180 |
HLA-DRB1*15:01 | QTPFEIKLAKKFDTFNG | QTPFEIKLAKKFDIFNG | 285 | 129 |
HLA-DRB1*15:01 | QTPFEIKLAKKFDTFN | QTPFEIKLAKKFDIFN | 307 | 139 |
HLA-DRB1*15:01 | ELQTPFEIKLAKKFDTFNG | ELQTPFEIKLAKKFDIFNG | 392 | 178 |
HLA-DRB1*15:01 | PFEIKLAKKFDTFNGEC | PFEIKLAKKFDIFNGEC | 317 | 144 |
HLA-DRB1*15:01 | LQTPFEIKLAKKFDTFNGE | LQTPFEIKLAKKFDIFNGE | 382 | 175 |
HLA-DRB1*15:01 | TPFEIKLAKKFDTFNGE | TPFEIKLAKKFDIFNGE | 289 | 133 |
HLA-DRB1*15:01 | TPFEIKLAKKFDTFNG | TPFEIKLAKKFDIFNG | 339 | 157 |
HLA-DRB1*15:01 | FEIKLAKKFDTFNGECPNF | FEIKLAKKFDIFNGECPNF | 517 | 240 |
HLA-DRB1*15:01 | PFEIKLAKKFDTFNGE | PFEIKLAKKFDIFNGE | 357 | 167 |
HLA-DRB1*15:01 | FEIKLAKKFDTFNGE | FEIKLAKKFDIFNGE | 192 | 90 |
HLA-DRB1*15:01 | LQTPFEIKLAKKFDTFN | LQTPFEIKLAKKFDIFN | 255 | 120 |
HLA-DRB1*15:01 | EIKLAKKFDTFNGECPN | EIKLAKKFDIFNGECPN | 616 | 292 |
HLA-DRB1*15:01 | EIKLAKKFDTFNGEC | EIKLAKKFDIFNGEC | 354 | 168 |
HLA-DRB1*15:01 | EIKLAKKFDTFNGECP | EIKLAKKFDIFNGECP | 725 | 346 |
HLA-DRB1*15:01 | YELQTPFEIKLAKKFDTF | YELQTPFEIKLAKKFDIF | 1005 | 480 |
HLA-DRB1*15:01 | QTPFEIKLAKKFDTF | QTPFEIKLAKKFDIF | 165 | 79 |
HLA-DRB1*15:01 | FEIKLAKKFDTFNGEC | FEIKLAKKFDIFNGEC | 382 | 183 |
HLA-DRB1*15:01 | EIKLAKKFDTFNGECPNFVF | EIKLAKKFDIFNGECPNFVF | 458 | 220 |
HLA-DRB1*15:01 | FEIKLAKKFDTFNGECP | FEIKLAKKFDIFNGECP | 329 | 160 |
HLA-DRB1*15:01 | LQTPFEIKLAKKFDTF | LQTPFEIKLAKKFDIF | 316 | 154 |
HLA-DRB1*15:01 | LQTPFEIKLAKKFDT | LQTPFEIKLAKKFDI | 293 | 143 |
HLA-DRB1*15:01 | PFEIKLAKKFDTFNGECPNF | PFEIKLAKKFDIFNGECPNF | 225 | 110 |
HLA-DRB1*15:01 | ELQTPFEIKLAKKFDT | ELQTPFEIKLAKKFDI | 630 | 309 |
HLA-DRB1*15:01 | YELQTPFEIKLAKKFDTFN | YELQTPFEIKLAKKFDIFN | 352 | 174 |
HLA-DRB1*15:01 | FEIKLAKKFDTFNGECPNFV | FEIKLAKKFDIFNGECPNFV | 272 | 135 |
HLA-DRB1*15:01 | LQTPFEIKLAKKFDTFNGEC | LQTPFEIKLAKKFDIFNGEC | 190 | 95 |
HLA-DRB1*15:01 | TPFEIKLAKKFDTFNGECPN | TPFEIKLAKKFDIFNGECPN | 208 | 104 |
Reference EEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSY
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Mutated EEAALCTFLLNKEMYLKLRSDVLLPPTQYNRYLVLYNKYKYFSGAMDTTSY
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | SDVLLPLTQYNRYLA | SDVLLPPTQYNRYLV | 184 | 1077 |
HLA-DRB1*15:01 | RSDVLLPLTQYNRYLA | RSDVLLPPTQYNRYLV | 385 | 2241 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLAL | SDVLLPPTQYNRYLVL | 246 | 1226 |
HLA-DRB1*15:01 | RSDVLLPLTQYNRYL | RSDVLLPPTQYNRYL | 466 | 2294 |
HLA-DRB1*15:01 | LRSDVLLPLTQYNRYLA | LRSDVLLPPTQYNRYLV | 351 | 1722 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLALY | DVLLPPTQYNRYLVLY | 203 | 946 |
HLA-DRB1*15:01 | LKLRSDVLLPLTQYNRYLA | LKLRSDVLLPPTQYNRYLV | 399 | 1842 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLAL | DVLLPPTQYNRYLVL | 119 | 546 |
HLA-DRB1*15:01 | RSDVLLPLTQYNRYLAL | RSDVLLPPTQYNRYLVL | 234 | 1060 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLALY | SDVLLPPTQYNRYLVLY | 190 | 838 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALY | VLLPPTQYNRYLVLY | 96 | 419 |
HLA-DRB1*15:01 | KLRSDVLLPLTQYNRYLAL | KLRSDVLLPPTQYNRYLVL | 313 | 1354 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLALYN | SDVLLPPTQYNRYLVLYN | 445 | 1800 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALYN | VLLPPTQYNRYLVLYN | 157 | 633 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLALYN | DVLLPPTQYNRYLVLYN | 150 | 567 |
HLA-DRB1*15:01 | LRSDVLLPLTQYNRYLALY | LRSDVLLPPTQYNRYLVLY | 273 | 1031 |
HLA-DRB1*15:01 | LKLRSDVLLPLTQYNRYLAL | LKLRSDVLLPPTQYNRYLVL | 179 | 658 |
HLA-DRB1*15:01 | KLRSDVLLPLTQYNRYLALY | KLRSDVLLPPTQYNRYLVLY | 162 | 585 |
HLA-DRB1*15:01 | RSDVLLPLTQYNRYLALYN | RSDVLLPPTQYNRYLVLYN | 205 | 705 |
HLA-DRB1*15:01 | LLPLTQYNRYLALYN | LLPPTQYNRYLVLYN | 80 | 273 |
HLA-DRB1*15:01 | YLKLRSDVLLPLTQYNRYLA | YLKLRSDVLLPPTQYNRYLV | 188 | 628 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLALYNK | DVLLPPTQYNRYLVLYNK | 405 | 1340 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALYNK | VLLPPTQYNRYLVLYNK | 131 | 386 |
HLA-DRB1*15:01 | LRSDVLLPLTQYNRYLALYN | LRSDVLLPPTQYNRYLVLYN | 123 | 353 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALYNKY | VLLPPTQYNRYLVLYNKY | 380 | 1086 |
HLA-DRB1*15:01 | LLPLTQYNRYLALYNK | LLPPTQYNRYLVLYNK | 157 | 447 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLALYNK | SDVLLPPTQYNRYLVLYNK | 178 | 490 |
HLA-DRB1*15:01 | LPLTQYNRYLALYNK | LPPTQYNRYLVLYNK | 79 | 208 |
HLA-DRB1*15:01 | RSDVLLPLTQYNRYLALYNK | RSDVLLPPTQYNRYLVLYNK | 101 | 250 |
HLA-DRB1*15:01 | LPLTQYNRYLALYNKY | LPPTQYNRYLVLYNKY | 165 | 406 |
HLA-DRB1*15:01 | YLKLRSDVLLPLTQYNR | YLKLRSDVLLPPTQYNR | 443 | 1090 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLALYNKY | DVLLPPTQYNRYLVLYNKY | 165 | 401 |
HLA-DRB1*15:01 | LLPLTQYNRYLALYNKY | LLPPTQYNRYLVLYNKY | 128 | 311 |
HLA-DRB1*15:01 | LLPLTQYNRYLALYNKYK | LLPPTQYNRYLVLYNKYK | 349 | 838 |
HLA-DRB1*15:01 | PLTQYNRYLALYNKY | PPTQYNRYLVLYNKY | 84 | 187 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLALYNKY | SDVLLPPTQYNRYLVLYNKY | 96 | 208 |
HLA-DRB1*15:01 | LPLTQYNRYLALYNKYK | LPPTQYNRYLVLYNKYK | 117 | 250 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALYNKYK | VLLPPTQYNRYLVLYNKYK | 136 | 287 |
HLA-DRB1*15:01 | YLKLRSDVLLPLTQY | YLKLRSDVLLPPTQY | 252 | 514 |
HLA-DRB1*15:01 | KEMYLKLRSDVLLPLTQY | KEMYLKLRSDVLLPPTQY | 456 | 919 |
HLA-DRB1*15:01 | PLTQYNRYLALYNKYK | PPTQYNRYLVLYNKYK | 161 | 323 |
Reference LLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCHL
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated LLNKEMYLKLRSDVLLPPTQYNRYLVLYNKYKYFSGAMDTTSYREAACCHL
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | SDVLLPLTQYNRYLA | SDVLLPPTQYNRYLV | 184 | 1077 |
HLA-DRB1*15:01 | RSDVLLPLTQYNRYLA | RSDVLLPPTQYNRYLV | 385 | 2241 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLAL | SDVLLPPTQYNRYLVL | 246 | 1226 |
HLA-DRB1*15:01 | LRSDVLLPLTQYNRYLA | LRSDVLLPPTQYNRYLV | 351 | 1722 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLALY | DVLLPPTQYNRYLVLY | 203 | 946 |
HLA-DRB1*15:01 | LKLRSDVLLPLTQYNRYLA | LKLRSDVLLPPTQYNRYLV | 399 | 1842 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLAL | DVLLPPTQYNRYLVL | 119 | 546 |
HLA-DRB1*15:01 | RSDVLLPLTQYNRYLAL | RSDVLLPPTQYNRYLVL | 234 | 1060 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLALY | SDVLLPPTQYNRYLVLY | 190 | 838 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALY | VLLPPTQYNRYLVLY | 96 | 419 |
HLA-DRB1*15:01 | KLRSDVLLPLTQYNRYLAL | KLRSDVLLPPTQYNRYLVL | 313 | 1354 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLALYN | SDVLLPPTQYNRYLVLYN | 445 | 1800 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALYN | VLLPPTQYNRYLVLYN | 157 | 633 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLALYN | DVLLPPTQYNRYLVLYN | 150 | 567 |
HLA-DRB1*15:01 | LRSDVLLPLTQYNRYLALY | LRSDVLLPPTQYNRYLVLY | 273 | 1031 |
HLA-DRB1*15:01 | LKLRSDVLLPLTQYNRYLAL | LKLRSDVLLPPTQYNRYLVL | 179 | 658 |
HLA-DRB1*15:01 | KLRSDVLLPLTQYNRYLALY | KLRSDVLLPPTQYNRYLVLY | 162 | 585 |
HLA-DRB1*15:01 | RSDVLLPLTQYNRYLALYN | RSDVLLPPTQYNRYLVLYN | 205 | 705 |
HLA-DRB1*15:01 | LLPLTQYNRYLALYN | LLPPTQYNRYLVLYN | 80 | 273 |
HLA-DRB1*15:01 | YLKLRSDVLLPLTQYNRYLA | YLKLRSDVLLPPTQYNRYLV | 188 | 628 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLALYNK | DVLLPPTQYNRYLVLYNK | 405 | 1340 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALYNK | VLLPPTQYNRYLVLYNK | 131 | 386 |
HLA-DRB1*15:01 | LRSDVLLPLTQYNRYLALYN | LRSDVLLPPTQYNRYLVLYN | 123 | 353 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALYNKY | VLLPPTQYNRYLVLYNKY | 380 | 1086 |
HLA-DRB1*15:01 | LLPLTQYNRYLALYNK | LLPPTQYNRYLVLYNK | 157 | 447 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLALYNK | SDVLLPPTQYNRYLVLYNK | 178 | 490 |
HLA-DRB1*15:01 | LPLTQYNRYLALYNK | LPPTQYNRYLVLYNK | 79 | 208 |
HLA-DRB1*15:01 | RSDVLLPLTQYNRYLALYNK | RSDVLLPPTQYNRYLVLYNK | 101 | 250 |
HLA-DRB1*15:01 | LPLTQYNRYLALYNKY | LPPTQYNRYLVLYNKY | 165 | 406 |
HLA-DRB1*15:01 | DVLLPLTQYNRYLALYNKY | DVLLPPTQYNRYLVLYNKY | 165 | 401 |
HLA-DRB1*15:01 | LLPLTQYNRYLALYNKY | LLPPTQYNRYLVLYNKY | 128 | 311 |
HLA-DRB1*15:01 | LLPLTQYNRYLALYNKYK | LLPPTQYNRYLVLYNKYK | 349 | 838 |
HLA-DRB1*15:01 | PLTQYNRYLALYNKY | PPTQYNRYLVLYNKY | 84 | 187 |
HLA-DRB1*15:01 | SDVLLPLTQYNRYLALYNKY | SDVLLPPTQYNRYLVLYNKY | 96 | 208 |
HLA-DRB1*15:01 | LPLTQYNRYLALYNKYK | LPPTQYNRYLVLYNKYK | 117 | 250 |
HLA-DRB1*15:01 | VLLPLTQYNRYLALYNKYK | VLLPPTQYNRYLVLYNKYK | 136 | 287 |
HLA-DRB1*15:01 | PLTQYNRYLALYNKYK | PPTQYNRYLVLYNKYK | 161 | 323 |
Reference FNMVYMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYD
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated FNMVYMPASWVMRIMTWLDMVDTSL‑‑‑KLKDCVMYASAVVLLILMTARTVYD
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | FKLKDCVMYASAVVL | KLKDCVMYASAVVL | 62 | - |
HLA-DRB1*15:01 | GFKLKDCVMYASAVV | KLKDCVMYASAVV | 110 | - |
HLA-DRB1*15:01 | GFKLKDCVMYASAVVLL | - | 117 | - |
HLA-DRB1*15:01 | FKLKDCVMYASAVVLLI | - | 125 | - |
HLA-DRB1*15:01 | SGFKLKDCVMYASAVVL | KLKDCVMYASAVVL | 126 | - |
HLA-DRB1*15:01 | FKLKDCVMYASAVVLL | - | 163 | - |
HLA-DRB1*15:01 | GFKLKDCVMYASAVVL | KLKDCVMYASAVVL | 171 | - |
HLA-DRB1*15:01 | MVDTSLSGFKLKDCVMYASAVVL | MVDTSLKLKDCVMYASAVVL | - | 195 |
HLA-DRB1*15:01 | VDTSLSGFKLKDCVMYASAVVLL | VDTSLKLKDCVMYASAVVLL | - | 204 |
HLA-DRB1*15:01 | LSGFKLKDCVMYASAVV | LKLKDCVMYASAVV | 217 | - |
HLA-DRB1*15:01 | DTSLSGFKLKDCVMYASAVVLLI | DTSLKLKDCVMYASAVVLLI | - | 224 |
HLA-DRB1*15:01 | TSLSGFKLKDCVMYASAVVLLIL | TSLKLKDCVMYASAVVLLIL | - | 231 |
HLA-DRB1*15:01 | SGFKLKDCVMYASAVVLLIL | - | 239 | - |
HLA-DRB1*15:01 | SLSGFKLKDCVMYASAVVLLILM | SLKLKDCVMYASAVVLLILM | - | 252 |
HLA-DRB1*15:01 | GFKLKDCVMYASAVVLLILM | - | 253 | - |
HLA-DRB1*15:01 | DMVDTSLSGFKLKDCVMYASAVV | DMVDTSLKLKDCVMYASAVV | - | 264 |
HLA-DRB1*15:01 | FKLKDCVMYASAVVLLILMT | - | 276 | - |
HLA-DRB1*15:01 | LSGFKLKDCVMYASAVVLLILMT | LKLKDCVMYASAVVLLILMT | - | 282 |
HLA-DRB1*15:01 | SGFKLKDCVMYASAVV | KLKDCVMYASAVV | 285 | - |
HLA-DRB1*15:01 | VDTSLSGFKLKDCVMYASAVVL | VDTSLKLKDCVMYASAVVL | - | 295 |
HLA-DRB1*15:01 | DTSLSGFKLKDCVMYASAVVLL | DTSLKLKDCVMYASAVVLL | - | 296 |
HLA-DRB1*15:01 | SGFKLKDCVMYASAVVLLI | - | 314 | - |
HLA-DRB1*15:01 | TSLSGFKLKDCVMYASAVVLLI | TSLKLKDCVMYASAVVLLI | - | 319 |
HLA-DRB1*15:01 | GFKLKDCVMYASAVVLLIL | - | 333 | - |
HLA-DRB1*15:01 | SLSGFKLKDCVMYASAVVLLIL | SLKLKDCVMYASAVVLLIL | - | 335 |
HLA-DRB1*15:01 | FKLKDCVMYASAVVLLILM | - | 358 | - |
HLA-DRB1*15:01 | LSGFKLKDCVMYASAVVLLILM | LKLKDCVMYASAVVLLILM | - | 361 |
HLA-DRB1*15:01 | MRIMTWLDMVDTSLS | MRIMTWLDMVDTSL | 382 | - |
HLA-DRB1*15:01 | SWVMRIMTWLDMVDTSLSGFKLK | SWVMRIMTWLDMVDTSLKLK | - | 401 |
HLA-DRB1*15:01 | MVDTSLSGFKLKDCVMYASAVV | MVDTSLKLKDCVMYASAVV | - | 441 |
HLA-DRB1*15:01 | ASWVMRIMTWLDMVDTSLSGFKL | ASWVMRIMTWLDMVDTSLKL | - | 459 |
HLA-DRB1*15:01 | WVMRIMTWLDMVDTSLSGFKLKD | WVMRIMTWLDMVDTSLKLKD | - | 466 |
HLA-DRB1*15:01 | LSGFKLKDCVMYASAVVL | LKLKDCVMYASAVVL | 630 | 61 |
HLA-DRB1*15:01 | SLSGFKLKDCVMYASAVV | SLKLKDCVMYASAVV | 1025 | 108 |
HLA-DRB1*15:01 | MRIMTWLDMVDTSLSGFK | MRIMTWLDMVDTSLK | 2429 | 340 |
Reference CVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHF
||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated CVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHF
Allele | Reference peptide | Mutated peptide | Reference affinity (IC50, nM) | Mutated affinity (IC50, nM) |
---|---|---|---|---|
HLA-DRB1*15:01 | FSTVFPPTSFGPLVRK | FSTVFPLTSFGPLVRK | 2472 | 145 |
HLA-DRB1*15:01 | STVFPPTSFGPLVRK | STVFPLTSFGPLVRK | 1187 | 73 |
HLA-DRB1*15:01 | FSTVFPPTSFGPLVR | FSTVFPLTSFGPLVR | 1497 | 93 |
HLA-DRB1*15:01 | STVFPPTSFGPLVRKI | STVFPLTSFGPLVRKI | 1911 | 131 |
HLA-DRB1*15:01 | FSTVFPPTSFGPLVRKI | FSTVFPLTSFGPLVRKI | 1398 | 104 |
HLA-DRB1*15:01 | TVFPPTSFGPLVRKI | TVFPLTSFGPLVRKI | 819 | 65 |
HLA-DRB1*15:01 | LFSTVFPPTSFGPLVRKI | LFSTVFPLTSFGPLVRKI | 4430 | 355 |
HLA-DRB1*15:01 | FSTVFPPTSFGPLVRKIF | FSTVFPLTSFGPLVRKIF | 3238 | 268 |
HLA-DRB1*15:01 | LFSTVFPPTSFGPLVRK | LFSTVFPLTSFGPLVRK | 1458 | 125 |
HLA-DRB1*15:01 | LFSTVFPPTSFGPLVR | LFSTVFPLTSFGPLVR | 2515 | 220 |
HLA-DRB1*15:01 | TVFPPTSFGPLVRKIF | TVFPLTSFGPLVRKIF | 1138 | 110 |
HLA-DRB1*15:01 | TVFPPTSFGPLVRKIFVD | TVFPLTSFGPLVRKIFVD | 3046 | 300 |
HLA-DRB1*15:01 | STVFPPTSFGPLVRKIFV | STVFPLTSFGPLVRKIFV | 2782 | 277 |
HLA-DRB1*15:01 | STVFPPTSFGPLVRKIF | STVFPLTSFGPLVRKIF | 895 | 92 |
HLA-DRB1*15:01 | VFPPTSFGPLVRKIFVDG | VFPLTSFGPLVRKIFVDG | 3100 | 329 |
HLA-DRB1*15:01 | VLFSTVFPPTSFGPLVRK | VLFSTVFPLTSFGPLVRK | 4258 | 469 |
HLA-DRB1*15:01 | VFPPTSFGPLVRKIFV | VFPLTSFGPLVRKIFV | 1011 | 116 |
HLA-DRB1*15:01 | LFSTVFPPTSFGPLVRKIF | LFSTVFPLTSFGPLVRKIF | 1264 | 147 |
HLA-DRB1*15:01 | VFPPTSFGPLVRKIF | VFPLTSFGPLVRKIF | 482 | 57 |
HLA-DRB1*15:01 | FPPTSFGPLVRKIFVD | FPLTSFGPLVRKIFVD | 1393 | 165 |
HLA-DRB1*15:01 | VLFSTVFPPTSFGPLVRKI | VLFSTVFPLTSFGPLVRKI | 1477 | 177 |
HLA-DRB1*15:01 | TVFPPTSFGPLVRKIFV | TVFPLTSFGPLVRKIFV | 774 | 96 |
HLA-DRB1*15:01 | VFPPTSFGPLVRKIFVD | VFPLTSFGPLVRKIFVD | 857 | 108 |
HLA-DRB1*15:01 | STVFPPTSFGPLVRKIFVD | STVFPLTSFGPLVRKIFVD | 1234 | 160 |
HLA-DRB1*15:01 | FSTVFPPTSFGPLVRKIFV | FSTVFPLTSFGPLVRKIFV | 1114 | 146 |
HLA-DRB1*15:01 | FPPTSFGPLVRKIFV | FPLTSFGPLVRKIFV | 551 | 76 |
HLA-DRB1*15:01 | NVLFSTVFPPTSFGPLVRK | NVLFSTVFPLTSFGPLVRK | 1483 | 205 |
HLA-DRB1*15:01 | FSTVFPPTSFGPLVRKIFVD | FSTVFPLTSFGPLVRKIFVD | 670 | 94 |
HLA-DRB1*15:01 | TVFPPTSFGPLVRKIFVDG | TVFPLTSFGPLVRKIFVDG | 1261 | 177 |
HLA-DRB1*15:01 | VLFSTVFPPTSFGPLVR | VLFSTVFPLTSFGPLVR | 1281 | 180 |
HLA-DRB1*15:01 | FPPTSFGPLVRKIFVDG | FPLTSFGPLVRKIFVDG | 1102 | 155 |
HLA-DRB1*15:01 | STVFPPTSFGPLVRKIFVDG | STVFPLTSFGPLVRKIFVDG | 705 | 100 |
HLA-DRB1*15:01 | NVLFSTVFPPTSFGPLVRKI | NVLFSTVFPLTSFGPLVRKI | 700 | 102 |
HLA-DRB1*15:01 | FPPTSFGPLVRKIFVDGV | FPLTSFGPLVRKIFVDGV | 3306 | 483 |
HLA-DRB1*15:01 | VLFSTVFPPTSFGPLVRKIF | VLFSTVFPLTSFGPLVRKIF | 595 | 89 |
HLA-DRB1*15:01 | LFSTVFPPTSFGPLVRKIFV | LFSTVFPLTSFGPLVRKIFV | 593 | 91 |
HLA-DRB1*15:01 | PPTSFGPLVRKIFVDG | PLTSFGPLVRKIFVDG | 1963 | 311 |
HLA-DRB1*15:01 | PPTSFGPLVRKIFVD | PLTSFGPLVRKIFVD | 902 | 143 |
HLA-DRB1*15:01 | VFPPTSFGPLVRKIFVDGV | VFPLTSFGPLVRKIFVDGV | 1195 | 195 |
HLA-DRB1*15:01 | TVFPPTSFGPLVRKIFVDGV | TVFPLTSFGPLVRKIFVDGV | 654 | 110 |
HLA-DRB1*15:01 | VFPPTSFGPLVRKIFVDGVP | VFPLTSFGPLVRKIFVDGVP | 656 | 125 |
HLA-DRB1*15:01 | LFSTVFPPTSFGPLV | LFSTVFPLTSFGPLV | 1566 | 306 |
HLA-DRB1*15:01 | FNVLFSTVFPPTSFGPLVRK | FNVLFSTVFPLTSFGPLVRK | 615 | 122 |
HLA-DRB1*15:01 | FPPTSFGPLVRKIFVDGVP | FPLTSFGPLVRKIFVDGVP | 1393 | 282 |
HLA-DRB1*15:01 | PPTSFGPLVRKIFVDGV | PLTSFGPLVRKIFVDGV | 1259 | 277 |
HLA-DRB1*15:01 | FNVLFSTVFPPTSFGPLVR | FNVLFSTVFPLTSFGPLVR | 1227 | 303 |
HLA-DRB1*15:01 | ANFNVLFSTVFPPTS | ANFNVLFSTVFPLTS | 287 | 72 |
HLA-DRB1*15:01 | HCANFNVLFSTVFPPTS | HCANFNVLFSTVFPLTS | 664 | 176 |
HLA-DRB1*15:01 | NVLFSTVFPPTSFGPLV | NVLFSTVFPLTSFGPLV | 1293 | 348 |
HLA-DRB1*15:01 | CANFNVLFSTVFPPTS | CANFNVLFSTVFPLTS | 873 | 236 |
HLA-DRB1*15:01 | CANFNVLFSTVFPPT | CANFNVLFSTVFPLT | 400 | 110 |
HLA-DRB1*15:01 | NFNVLFSTVFPPTSF | NFNVLFSTVFPLTSF | 272 | 78 |
HLA-DRB1*15:01 | NVLFSTVFPPTSFGP | NVLFSTVFPLTSFGP | 674 | 198 |
HLA-DRB1*15:01 | NFNVLFSTVFPPTSFGPLVR | NFNVLFSTVFPLTSFGPLVR | 571 | 168 |
HLA-DRB1*15:01 | NVLFSTVFPPTSFGPL | NVLFSTVFPLTSFGPL | 1664 | 493 |
HLA-DRB1*15:01 | FPPTSFGPLVRKIFVDGVPF | FPLTSFGPLVRKIFVDGVPF | 591 | 177 |
HLA-DRB1*15:01 | HCANFNVLFSTVFPP | HCANFNVLFSTVFPL | 654 | 209 |
HLA-DRB1*15:01 | NFNVLFSTVFPPTSFGP | NFNVLFSTVFPLTSFGP | 610 | 195 |
HLA-DRB1*15:01 | LHCANFNVLFSTVFPPT | LHCANFNVLFSTVFPLT | 801 | 261 |
HLA-DRB1*15:01 | NFNVLFSTVFPPTSFG | NFNVLFSTVFPLTSFG | 778 | 256 |
HLA-DRB1*15:01 | CANFNVLFSTVFPPTSF | CANFNVLFSTVFPLTSF | 516 | 170 |
HLA-DRB1*15:01 | PTSFGPLVRKIFVDG | LTSFGPLVRKIFVDG | 1116 | 369 |
HLA-DRB1*15:01 | HCANFNVLFSTVFPPT | HCANFNVLFSTVFPLT | 1018 | 341 |
HLA-DRB1*15:01 | ANFNVLFSTVFPPTSFG | ANFNVLFSTVFPLTSFG | 519 | 177 |
HLA-DRB1*15:01 | ANFNVLFSTVFPPTSF | ANFNVLFSTVFPLTSF | 645 | 228 |
HLA-DRB1*15:01 | FNVLFSTVFPPTSFG | FNVLFSTVFPLTSFG | 381 | 139 |
HLA-DRB1*15:01 | VLFSTVFPPTSFGPL | VLFSTVFPLTSFGPL | 860 | 324 |
HLA-DRB1*15:01 | FNVLFSTVFPPTSFGPL | FNVLFSTVFPLTSFGPL | 784 | 296 |
HLA-DRB1*15:01 | PPTSFGPLVRKIFVDGVPF | PLTSFGPLVRKIFVDGVPF | 1177 | 454 |
HLA-DRB1*15:01 | FNVLFSTVFPPTSFGP | FNVLFSTVFPLTSFGP | 1032 | 415 |
HLA-DRB1*15:01 | NFNVLFSTVFPPTSFGPLV | NFNVLFSTVFPLTSFGPLV | 1075 | 460 |
HLA-DRB1*15:01 | ILHCANFNVLFSTVFPP | ILHCANFNVLFSTVFPL | 866 | 387 |
HLA-DRB1*15:01 | ILHCANFNVLFSTVFPPTS | ILHCANFNVLFSTVFPLTS | 912 | 424 |
HLA-DRB1*15:01 | ANFNVLFSTVFPPTSFGPL | ANFNVLFSTVFPLTSFGPL | 955 | 453 |
HLA-DRB1*15:01 | CANFNVLFSTVFPPTSFGP | CANFNVLFSTVFPLTSFGP | 950 | 474 |