Summary

This strain contains 11 protein-level mutations:

  • 4 mutations in Spike protein: S13I, W152C, L452R, D614G
  • 1 mutation in N protein: T205I
  • 2 mutations in NS3 protein: Q57H, A99V
  • 1 mutation in NS9c protein: L52F
  • 1 mutation in NSP2 protein: T85I
  • 1 mutation in NSP12 protein: P323L
  • 1 mutation in NSP13 protein: D260Y

We identified all possible linear viral peptides affected by these mutations. Whenever it was possible, we matched the reference peptide with the mutated one. For example, D -> L mutation transformed SDNGPQNQR to SLNGPQNQR. Cases when it was not meaningful included deletions and insertions at the flanks of the peptide, e.g., HV deletion in NVTWFHAIHV peptide.

Then, we predicted binding affinities between the selected peptides and frequent HLA alleles. Predictions were made with NetMHCpan-4.1 and NetMHCIIpan-4.0. The binding affinities were classifies into three groups:

  1. Tight binding (IC50 affinity ≤ 50 nM)
  2. Moderate binding (50 nM < IC50 affinity ≤ 500 nM)
  3. Weak/no binding (IC50 affinity > 500 nM)

Here we report HLA-peptide interactions whose affinity was altered by at least two folds. Note that mutations with empty set of altered interactions are not showed.

The total number of interactions between HLA-DPA1*03:01/DPB1*04:01 and peptides affected by the mutations

Weaker binding was found for 69 epitopes, while stronger binding was found for 99 entries. There are 2314 tight binders for the HLA-DPA1*03:01/DPB1*04:01 in the reference immunopeptidome (IC50 affinity ≤ 50 nM); 0 of them became non-tight binders (0.0%) and 10 novel tight binders appeared (0.4%). To avoid possible divisions by zero, we used + 1 regularization term in denominators when calculating percentages.

HLA-DPA1*03:01/DPB1*04:01

Spike protein

W152C

Reference  VIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLM
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Mutated    VIKVCEFQFCNDPFLGVYYHKNNKSCMESEFRVYSSANNCTFEYVSQPFLM

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DPA1*03:01/DPB1*04:01 HKNNKSWMESEFRVYS HKNNKSCMESEFRVYS 166 793
HLA-DPA1*03:01/DPB1*04:01 YHKNNKSWMESEFRVY YHKNNKSCMESEFRVY 210 1000
HLA-DPA1*03:01/DPB1*04:01 YYHKNNKSWMESEFRVYS YYHKNNKSCMESEFRVYS 408 1879
HLA-DPA1*03:01/DPB1*04:01 HKNNKSWMESEFRVYSSA HKNNKSCMESEFRVYSSA 321 1470
HLA-DPA1*03:01/DPB1*04:01 YHKNNKSWMESEFRVYSS YHKNNKSCMESEFRVYSS 372 1703
HLA-DPA1*03:01/DPB1*04:01 KNNKSWMESEFRVYSS KNNKSCMESEFRVYSS 158 709
HLA-DPA1*03:01/DPB1*04:01 KNNKSWMESEFRVYSSAN KNNKSCMESEFRVYSSAN 343 1535
HLA-DPA1*03:01/DPB1*04:01 VYYHKNNKSWMESEFRVYS VYYHKNNKSCMESEFRVYS 207 917
HLA-DPA1*03:01/DPB1*04:01 YYHKNNKSWMESEFRVYSS YYHKNNKSCMESEFRVYSS 185 812
HLA-DPA1*03:01/DPB1*04:01 GVYYHKNNKSWMESEFRVYS GVYYHKNNKSCMESEFRVYS 164 699
HLA-DPA1*03:01/DPB1*04:01 GVYYHKNNKSWMESEFRVY GVYYHKNNKSCMESEFRVY 275 1172
HLA-DPA1*03:01/DPB1*04:01 NNKSWMESEFRVYSSA NNKSCMESEFRVYSSA 144 611
HLA-DPA1*03:01/DPB1*04:01 YYHKNNKSWMESEFRVY YYHKNNKSCMESEFRVY 272 1147
HLA-DPA1*03:01/DPB1*04:01 YHKNNKSWMESEFRVYSSA YHKNNKSCMESEFRVYSSA 157 661
HLA-DPA1*03:01/DPB1*04:01 NKSWMESEFRVYSSAN NKSCMESEFRVYSSAN 160 672
HLA-DPA1*03:01/DPB1*04:01 YHKNNKSWMESEFRVYS YHKNNKSCMESEFRVYS 200 840
HLA-DPA1*03:01/DPB1*04:01 LGVYYHKNNKSWMESEFRVY LGVYYHKNNKSCMESEFRVY 208 866
HLA-DPA1*03:01/DPB1*04:01 HKNNKSWMESEFRVYSSAN HKNNKSCMESEFRVYSSAN 166 688
HLA-DPA1*03:01/DPB1*04:01 VYYHKNNKSWMESEFRVYSS VYYHKNNKSCMESEFRVYSS 145 589
HLA-DPA1*03:01/DPB1*04:01 HKNNKSWMESEFRVY HKNNKSCMESEFRVY 187 759
HLA-DPA1*03:01/DPB1*04:01 YYHKNNKSWMESEFRVYSSA YYHKNNKSCMESEFRVYSSA 122 493
HLA-DPA1*03:01/DPB1*04:01 HKNNKSWMESEFRVYSS HKNNKSCMESEFRVYSS 187 752
HLA-DPA1*03:01/DPB1*04:01 KNNKSWMESEFRVYS KNNKSCMESEFRVYS 152 606
HLA-DPA1*03:01/DPB1*04:01 YHKNNKSWMESEFRVYSSAN YHKNNKSCMESEFRVYSSAN 126 498
HLA-DPA1*03:01/DPB1*04:01 NNKSWMESEFRVYSS NNKSCMESEFRVYSS 153 593
HLA-DPA1*03:01/DPB1*04:01 NNKSWMESEFRVYSSANN NNKSCMESEFRVYSSANN 332 1283
HLA-DPA1*03:01/DPB1*04:01 KNNKSWMESEFRVYSSA KNNKSCMESEFRVYSSA 164 632
HLA-DPA1*03:01/DPB1*04:01 NNKSWMESEFRVYSSAN NNKSCMESEFRVYSSAN 180 690
HLA-DPA1*03:01/DPB1*04:01 KSWMESEFRVYSSAN KSCMESEFRVYSSAN 169 643
HLA-DPA1*03:01/DPB1*04:01 NKSWMESEFRVYSSA NKSCMESEFRVYSSA 145 541
HLA-DPA1*03:01/DPB1*04:01 NKSWMESEFRVYSSANNC NKSCMESEFRVYSSANNC 344 1263
HLA-DPA1*03:01/DPB1*04:01 KSWMESEFRVYSSANN KSCMESEFRVYSSANN 171 624
HLA-DPA1*03:01/DPB1*04:01 KNNKSWMESEFRVYSSANN KNNKSCMESEFRVYSSANN 162 571
HLA-DPA1*03:01/DPB1*04:01 KSWMESEFRVYSSANNCT KSCMESEFRVYSSANNCT 404 1352
HLA-DPA1*03:01/DPB1*04:01 HKNNKSWMESEFRVYSSANN HKNNKSCMESEFRVYSSANN 120 400
HLA-DPA1*03:01/DPB1*04:01 NNKSWMESEFRVYSSANNC NNKSCMESEFRVYSSANNC 167 556
HLA-DPA1*03:01/DPB1*04:01 NKSWMESEFRVYSSANN NKSCMESEFRVYSSANN 186 614
HLA-DPA1*03:01/DPB1*04:01 NKSWMESEFRVYSSANNCT NKSCMESEFRVYSSANNCT 184 588
HLA-DPA1*03:01/DPB1*04:01 KNNKSWMESEFRVYSSANNC KNNKSCMESEFRVYSSANNC 121 385
HLA-DPA1*03:01/DPB1*04:01 KSWMESEFRVYSSANNC KSCMESEFRVYSSANNC 203 638
HLA-DPA1*03:01/DPB1*04:01 NNKSWMESEFRVYSSANNCT NNKSCMESEFRVYSSANNCT 131 385
HLA-DPA1*03:01/DPB1*04:01 SWMESEFRVYSSANN SCMESEFRVYSSANN 323 949
HLA-DPA1*03:01/DPB1*04:01 SWMESEFRVYSSANNC SCMESEFRVYSSANNC 333 916
HLA-DPA1*03:01/DPB1*04:01 KSWMESEFRVYSSANNCTF KSCMESEFRVYSSANNCTF 203 534
HLA-DPA1*03:01/DPB1*04:01 NKSWMESEFRVYSSANNCTF NKSCMESEFRVYSSANNCTF 135 345
HLA-DPA1*03:01/DPB1*04:01 KSWMESEFRVYSSANNCTFE KSCMESEFRVYSSANNCTFE 161 387
HLA-DPA1*03:01/DPB1*04:01 SWMESEFRVYSSANNCT SCMESEFRVYSSANNCT 399 959

L452R

Reference  DDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGS
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Mutated    DDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGS

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DPA1*03:01/DPB1*04:01 DSKVGGNYNYLYRLFR DSKVGGNYNYRYRLFR 392 2542
HLA-DPA1*03:01/DPB1*04:01 NLDSKVGGNYNYLYRLFRK NLDSKVGGNYNYRYRLFRK 305 1960
HLA-DPA1*03:01/DPB1*04:01 NNLDSKVGGNYNYLYRLFRK NNLDSKVGGNYNYRYRLFRK 256 1631
HLA-DPA1*03:01/DPB1*04:01 SNNLDSKVGGNYNYLYRLFR SNNLDSKVGGNYNYRYRLFR 345 2181
HLA-DPA1*03:01/DPB1*04:01 SKVGGNYNYLYRLFR SKVGGNYNYRYRLFR 359 2266
HLA-DPA1*03:01/DPB1*04:01 NNLDSKVGGNYNYLYRLFR NNLDSKVGGNYNYRYRLFR 401 2531
HLA-DPA1*03:01/DPB1*04:01 LDSKVGGNYNYLYRLFR LDSKVGGNYNYRYRLFR 441 2693
HLA-DPA1*03:01/DPB1*04:01 KVGGNYNYLYRLFRK KVGGNYNYRYRLFRK 305 1801
HLA-DPA1*03:01/DPB1*04:01 SKVGGNYNYLYRLFRK SKVGGNYNYRYRLFRK 309 1809
HLA-DPA1*03:01/DPB1*04:01 DSKVGGNYNYLYRLFRK DSKVGGNYNYRYRLFRK 351 2010
HLA-DPA1*03:01/DPB1*04:01 LDSKVGGNYNYLYRLFRKS LDSKVGGNYNYRYRLFRKS 200 617
HLA-DPA1*03:01/DPB1*04:01 DSKVGGNYNYLYRLFRKSN DSKVGGNYNYRYRLFRKSN 193 592
HLA-DPA1*03:01/DPB1*04:01 SKVGGNYNYLYRLFRKSN SKVGGNYNYRYRLFRKSN 356 1062
HLA-DPA1*03:01/DPB1*04:01 DSKVGGNYNYLYRLFRKS DSKVGGNYNYRYRLFRKS 366 1087
HLA-DPA1*03:01/DPB1*04:01 KVGGNYNYLYRLFRKS KVGGNYNYRYRLFRKS 191 530
HLA-DPA1*03:01/DPB1*04:01 NLDSKVGGNYNYLYRLFRKS NLDSKVGGNYNYRYRLFRKS 174 481
HLA-DPA1*03:01/DPB1*04:01 LDSKVGGNYNYLYRLFRKSN LDSKVGGNYNYRYRLFRKSN 166 442
HLA-DPA1*03:01/DPB1*04:01 SKVGGNYNYLYRLFRKS SKVGGNYNYRYRLFRKS 212 546
HLA-DPA1*03:01/DPB1*04:01 KVGGNYNYLYRLFRKSN KVGGNYNYRYRLFRKSN 214 546
HLA-DPA1*03:01/DPB1*04:01 VGGNYNYLYRLFRKSN VGGNYNYRYRLFRKSN 215 536
HLA-DPA1*03:01/DPB1*04:01 VGGNYNYLYRLFRKS VGGNYNYRYRLFRKS 198 415

D614G

Reference  PCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG
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Mutated    PCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYSTG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DPA1*03:01/DPB1*04:01 GTNTSNQVAVLYQDV GTNTSNQVAVLYQGV 307 635

NSP12 protein

P323L

Reference  CVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHF
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    CVNCLDDRCILHCANFNVLFSTVFPLTSFGPLVRKIFVDGVPFVVSTGYHF

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DPA1*03:01/DPB1*04:01 FSTVFPPTSFGPLVRKIF FSTVFPLTSFGPLVRKIF 973 117
HLA-DPA1*03:01/DPB1*04:01 STVFPPTSFGPLVRKI STVFPLTSFGPLVRKI 674 84
HLA-DPA1*03:01/DPB1*04:01 FSTVFPPTSFGPLVRK FSTVFPLTSFGPLVRK 602 78
HLA-DPA1*03:01/DPB1*04:01 STVFPPTSFGPLVRKIFV STVFPLTSFGPLVRKIFV 1016 133
HLA-DPA1*03:01/DPB1*04:01 FSTVFPPTSFGPLVRKI FSTVFPLTSFGPLVRKI 650 87
HLA-DPA1*03:01/DPB1*04:01 TVFPPTSFGPLVRKIFVD TVFPLTSFGPLVRKIFVD 1267 174
HLA-DPA1*03:01/DPB1*04:01 LFSTVFPPTSFGPLVRKI LFSTVFPLTSFGPLVRKI 650 94
HLA-DPA1*03:01/DPB1*04:01 STVFPPTSFGPLVRK STVFPLTSFGPLVRK 560 83
HLA-DPA1*03:01/DPB1*04:01 FSTVFPPTSFGPLVR FSTVFPLTSFGPLVR 582 88
HLA-DPA1*03:01/DPB1*04:01 TVFPPTSFGPLVRKIF TVFPLTSFGPLVRKIF 633 96
HLA-DPA1*03:01/DPB1*04:01 STVFPPTSFGPLVRKIF STVFPLTSFGPLVRKIF 600 93
HLA-DPA1*03:01/DPB1*04:01 TVFPPTSFGPLVRKI TVFPLTSFGPLVRKI 656 102
HLA-DPA1*03:01/DPB1*04:01 FSTVFPPTSFGPLVRKIFV FSTVFPLTSFGPLVRKIFV 536 91
HLA-DPA1*03:01/DPB1*04:01 VFPPTSFGPLVRKIFVDG VFPLTSFGPLVRKIFVDG 1518 259
HLA-DPA1*03:01/DPB1*04:01 TVFPPTSFGPLVRKIFV TVFPLTSFGPLVRKIFV 678 117
HLA-DPA1*03:01/DPB1*04:01 STVFPPTSFGPLVRKIFVD STVFPLTSFGPLVRKIFVD 614 106
HLA-DPA1*03:01/DPB1*04:01 VFPPTSFGPLVRKIF VFPLTSFGPLVRKIF 700 132
HLA-DPA1*03:01/DPB1*04:01 VFPPTSFGPLVRKIFVD VFPLTSFGPLVRKIFVD 934 179
HLA-DPA1*03:01/DPB1*04:01 VFPPTSFGPLVRKIFV VFPLTSFGPLVRKIFV 752 145
HLA-DPA1*03:01/DPB1*04:01 LFSTVFPPTSFGPLVRK LFSTVFPLTSFGPLVRK 319 63
HLA-DPA1*03:01/DPB1*04:01 FSTVFPPTSFGPLVRKIFVD FSTVFPLTSFGPLVRKIFVD 448 90
HLA-DPA1*03:01/DPB1*04:01 TVFPPTSFGPLVRKIFVDG TVFPLTSFGPLVRKIFVDG 720 145
HLA-DPA1*03:01/DPB1*04:01 LFSTVFPPTSFGPLVR LFSTVFPLTSFGPLVR 330 67
HLA-DPA1*03:01/DPB1*04:01 STVFPPTSFGPLVRKIFVDG STVFPLTSFGPLVRKIFVDG 503 106
HLA-DPA1*03:01/DPB1*04:01 LFSTVFPPTSFGPLVRKIF LFSTVFPLTSFGPLVRKIF 338 72
HLA-DPA1*03:01/DPB1*04:01 FPPTSFGPLVRKIFVD FPLTSFGPLVRKIFVD 1381 341
HLA-DPA1*03:01/DPB1*04:01 LFSTVFPPTSFGPLV LFSTVFPLTSFGPLV 276 69
HLA-DPA1*03:01/DPB1*04:01 TVFPPTSFGPLVRKIFVDGV TVFPLTSFGPLVRKIFVDGV 515 133
HLA-DPA1*03:01/DPB1*04:01 LFSTVFPPTSFGPLVRKIFV LFSTVFPLTSFGPLVRKIFV 277 73
HLA-DPA1*03:01/DPB1*04:01 VFPPTSFGPLVRKIFVDGV VFPLTSFGPLVRKIFVDGV 769 206
HLA-DPA1*03:01/DPB1*04:01 VLFSTVFPPTSFGPLVRK VLFSTVFPLTSFGPLVRK 223 61
HLA-DPA1*03:01/DPB1*04:01 FPPTSFGPLVRKIFV FPLTSFGPLVRKIFV 1137 319
HLA-DPA1*03:01/DPB1*04:01 FPPTSFGPLVRKIFVDG FPLTSFGPLVRKIFVDG 1369 390
HLA-DPA1*03:01/DPB1*04:01 NVLFSTVFPPTSFGPLVR NVLFSTVFPLTSFGPLVR 153 48
HLA-DPA1*03:01/DPB1*04:01 VFPPTSFGPLVRKIFVDGVP VFPLTSFGPLVRKIFVDGVP 575 187
HLA-DPA1*03:01/DPB1*04:01 VLFSTVFPPTSFGPLVRKI VLFSTVFPLTSFGPLVRKI 137 50
HLA-DPA1*03:01/DPB1*04:01 VLFSTVFPPTSFGPLVR VLFSTVFPLTSFGPLVR 112 41
HLA-DPA1*03:01/DPB1*04:01 VLFSTVFPPTSFGPLV VLFSTVFPLTSFGPLV 112 43
HLA-DPA1*03:01/DPB1*04:01 FPPTSFGPLVRKIFVDGVP FPLTSFGPLVRKIFVDGVP 954 369
HLA-DPA1*03:01/DPB1*04:01 NVLFSTVFPPTSFGPLV NVLFSTVFPLTSFGPLV 71 28
HLA-DPA1*03:01/DPB1*04:01 VLFSTVFPPTSFGPLVRKIF VLFSTVFPLTSFGPLVRKIF 127 52
HLA-DPA1*03:01/DPB1*04:01 NVLFSTVFPPTSFGPLVRK NVLFSTVFPLTSFGPLVRK 83 34
HLA-DPA1*03:01/DPB1*04:01 NVLFSTVFPPTSFGPL NVLFSTVFPLTSFGPL 70 29
HLA-DPA1*03:01/DPB1*04:01 VLFSTVFPPTSFGPL VLFSTVFPLTSFGPL 86 36
HLA-DPA1*03:01/DPB1*04:01 HCANFNVLFSTVFPP HCANFNVLFSTVFPL 141 64
HLA-DPA1*03:01/DPB1*04:01 NVLFSTVFPPTSFGPLVRKI NVLFSTVFPLTSFGPLVRKI 79 37
HLA-DPA1*03:01/DPB1*04:01 NVLFSTVFPPTSFGP NVLFSTVFPLTSFGP 56 27
HLA-DPA1*03:01/DPB1*04:01 LHCANFNVLFSTVFPP LHCANFNVLFSTVFPL 138 67

NSP13 protein

D260Y

Reference  LSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPG
           ||||||||||||||||||||||||| |||||||||||||||||||||||||
Mutated    LSAPTLVPQEHYVRITGLYPTLNISYEFSSNVANYQKVGMQKYSTLQGPPG

Export table to csv 
Allele Reference peptide Mutated peptide Reference affinity (IC50, nM) Mutated affinity (IC50, nM)
HLA-DPA1*03:01/DPB1*04:01 YPTLNISDEFSSNVANY YPTLNISYEFSSNVANY 1796 272
HLA-DPA1*03:01/DPB1*04:01 PTLNISDEFSSNVANY PTLNISYEFSSNVANY 1927 303
HLA-DPA1*03:01/DPB1*04:01 GLYPTLNISDEFSSNVANY GLYPTLNISYEFSSNVANY 1380 226
HLA-DPA1*03:01/DPB1*04:01 LYPTLNISDEFSSNVANY LYPTLNISYEFSSNVANY 2935 499
HLA-DPA1*03:01/DPB1*04:01 LYPTLNISDEFSSNVAN LYPTLNISYEFSSNVAN 1684 294
HLA-DPA1*03:01/DPB1*04:01 PTLNISDEFSSNVANYQ PTLNISYEFSSNVANYQ 1719 301
HLA-DPA1*03:01/DPB1*04:01 GLYPTLNISDEFSSNVA GLYPTLNISYEFSSNVA 1496 271
HLA-DPA1*03:01/DPB1*04:01 YPTLNISDEFSSNVAN YPTLNISYEFSSNVAN 1828 334
HLA-DPA1*03:01/DPB1*04:01 TLNISDEFSSNVANY TLNISYEFSSNVANY 1892 352
HLA-DPA1*03:01/DPB1*04:01 LYPTLNISDEFSSNVA LYPTLNISYEFSSNVA 1597 304
HLA-DPA1*03:01/DPB1*04:01 TGLYPTLNISDEFSSNVA TGLYPTLNISYEFSSNVA 2548 486
HLA-DPA1*03:01/DPB1*04:01 TLNISDEFSSNVANYQ TLNISYEFSSNVANYQ 1593 304
HLA-DPA1*03:01/DPB1*04:01 TLNISDEFSSNVANYQK TLNISYEFSSNVANYQK 1609 311
HLA-DPA1*03:01/DPB1*04:01 TGLYPTLNISDEFSSNVAN TGLYPTLNISYEFSSNVAN 1323 256
HLA-DPA1*03:01/DPB1*04:01 PTLNISDEFSSNVAN PTLNISYEFSSNVAN 2057 404
HLA-DPA1*03:01/DPB1*04:01 TGLYPTLNISDEFSSNV TGLYPTLNISYEFSSNV 1543 306
HLA-DPA1*03:01/DPB1*04:01 LYPTLNISDEFSSNVANYQ LYPTLNISYEFSSNVANYQ 1284 257
HLA-DPA1*03:01/DPB1*04:01 GLYPTLNISDEFSSNV GLYPTLNISYEFSSNV 1617 324
HLA-DPA1*03:01/DPB1*04:01 LNISDEFSSNVANYQK LNISYEFSSNVANYQK 1715 346
HLA-DPA1*03:01/DPB1*04:01 YPTLNISDEFSSNVANYQK YPTLNISYEFSSNVANYQK 1281 266
HLA-DPA1*03:01/DPB1*04:01 YPTLNISDEFSSNVA YPTLNISYEFSSNVA 1660 347
HLA-DPA1*03:01/DPB1*04:01 TGLYPTLNISDEFSSNVANY TGLYPTLNISYEFSSNVANY 746 159
HLA-DPA1*03:01/DPB1*04:01 LYPTLNISDEFSSNV LYPTLNISYEFSSNV 1680 367
HLA-DPA1*03:01/DPB1*04:01 GLYPTLNISDEFSSNVANYQ GLYPTLNISYEFSSNVANYQ 729 161
HLA-DPA1*03:01/DPB1*04:01 LYPTLNISDEFSSNVANYQK LYPTLNISYEFSSNVANYQK 754 170
HLA-DPA1*03:01/DPB1*04:01 ITGLYPTLNISDEFSSNVA ITGLYPTLNISYEFSSNVA 1067 241
HLA-DPA1*03:01/DPB1*04:01 ITGLYPTLNISDEFSSNV ITGLYPTLNISYEFSSNV 2194 499
HLA-DPA1*03:01/DPB1*04:01 LNISDEFSSNVANYQ LNISYEFSSNVANYQ 1924 440
HLA-DPA1*03:01/DPB1*04:01 ITGLYPTLNISDEFSSNVAN ITGLYPTLNISYEFSSNVAN 694 176
HLA-DPA1*03:01/DPB1*04:01 PTLNISDEFSSNVANYQKVG PTLNISYEFSSNVANYQKVG 710 188
HLA-DPA1*03:01/DPB1*04:01 YPTLNISDEFSSNVANYQKV YPTLNISYEFSSNVANYQKV 634 168
HLA-DPA1*03:01/DPB1*04:01 LNISDEFSSNVANYQKV LNISYEFSSNVANYQKV 1320 352
HLA-DPA1*03:01/DPB1*04:01 PTLNISDEFSSNVANYQKV PTLNISYEFSSNVANYQKV 991 266
HLA-DPA1*03:01/DPB1*04:01 TLNISDEFSSNVANYQKVG TLNISYEFSSNVANYQKVG 1157 311
HLA-DPA1*03:01/DPB1*04:01 RITGLYPTLNISDEFSSNV RITGLYPTLNISYEFSSNV 996 275
HLA-DPA1*03:01/DPB1*04:01 ITGLYPTLNISDEFSSN ITGLYPTLNISYEFSSN 1509 419
HLA-DPA1*03:01/DPB1*04:01 ITGLYPTLNISDEFSS ITGLYPTLNISYEFSS 1556 452
HLA-DPA1*03:01/DPB1*04:01 TLNISDEFSSNVANYQKVGM TLNISYEFSSNVANYQKVGM 702 205
HLA-DPA1*03:01/DPB1*04:01 RITGLYPTLNISDEFSSNVA RITGLYPTLNISYEFSSNVA 616 185
HLA-DPA1*03:01/DPB1*04:01 ITGLYPTLNISDEFS ITGLYPTLNISYEFS 1405 449
HLA-DPA1*03:01/DPB1*04:01 LNISDEFSSNVANYQKVGM LNISYEFSSNVANYQKVGM 1213 388
HLA-DPA1*03:01/DPB1*04:01 RITGLYPTLNISDEFSS RITGLYPTLNISYEFSS 1269 422
HLA-DPA1*03:01/DPB1*04:01 LNISDEFSSNVANYQKVGMQ LNISYEFSSNVANYQKVGMQ 802 268
HLA-DPA1*03:01/DPB1*04:01 NISDEFSSNVANYQKV NISYEFSSNVANYQKV 1313 440
HLA-DPA1*03:01/DPB1*04:01 RITGLYPTLNISDEFS RITGLYPTLNISYEFS 1165 414
HLA-DPA1*03:01/DPB1*04:01 VRITGLYPTLNISDEFSSNV VRITGLYPTLNISYEFSSNV 541 200
HLA-DPA1*03:01/DPB1*04:01 RITGLYPTLNISDEF RITGLYPTLNISYEF 1102 429
HLA-DPA1*03:01/DPB1*04:01 NISDEFSSNVANYQKVGMQK NISYEFSSNVANYQKVGMQK 947 382
HLA-DPA1*03:01/DPB1*04:01 VRITGLYPTLNISDEFSSN VRITGLYPTLNISYEFSSN 790 331
HLA-DPA1*03:01/DPB1*04:01 VRITGLYPTLNISDEFS VRITGLYPTLNISYEFS 791 352
HLA-DPA1*03:01/DPB1*04:01 VRITGLYPTLNISDEF VRITGLYPTLNISYEF 754 353